Version 5.4
Homo sapiens Gene: PALM
Summary
InnateDB Gene IDBG-12777.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PALM
Gene Name paralemmin
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000099864
Encoded Proteins
IDBP-12779
paralemmin
IDBP-12781
paralemmin
IDBP-809462
paralemmin
IDBP-809452
paralemmin
IDBP-809461
paralemmin
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the paralemmin protein family. The product of this gene is a prenylated and palmitoylated phosphoprotein that associates with the cytoplasmic face of plasma membranes and is implicated in plasma membrane dynamics in neurons and other cell types. Several alternatively spliced transcript variants have been identified, but the full-length nature of only two transcript variants has been determined. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:709093-748330
Strand Forward strand
Band p13.3
Transcripts
ENST00000338448 ENSP00000341911
ENST00000264560 ENSP00000264560
ENST00000593172
ENST00000590161 ENSP00000480594
ENST00000586055 ENSP00000484090
ENST00000589012
ENST00000592870
ENST00000586776
ENST00000587513
ENST00000592155 ENSP00000477952
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0031750 D3 dopamine receptor binding
Biological Process
GO:0006928 cellular component movement
GO:0007010 cytoskeleton organization
GO:0007194 negative regulation of adenylate cyclase activity
GO:0008104 protein localization
GO:0008360 regulation of cell shape
GO:0030818 negative regulation of cAMP biosynthetic process
GO:0051491 positive regulation of filopodium assembly
GO:0060074 synapse maturation
GO:0060160 negative regulation of dopamine receptor signaling pathway
GO:0060999 positive regulation of dendritic spine development
GO:0071257 cellular response to electrical stimulus
GO:0072661 protein targeting to plasma membrane
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016023 cytoplasmic membrane-bounded vesicle
GO:0016323 basolateral plasma membrane
GO:0016327 apicolateral plasma membrane
GO:0030175 filopodium
GO:0030424 axon
GO:0031527 filopodium membrane
GO:0032590 dendrite membrane
GO:0032591 dendritic spine membrane
GO:0044309 neuron spine
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000035863
View Gene Order
ENSBTAG00000019771
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 5064
UniGene
RefSeq NM_001040134 NM_002579 XM_005259565 XM_005259566 XM_006722761
HUGO HGNC:8594
OMIM 608134
CCDS CCDS32857 CCDS32858
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas 5064

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca