Version 5.4
Homo sapiens Protein: PALM
Summary
InnateDB Protein IDBP-12781.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PALM
Protein Name paralemmin
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000264560
InnateDB Gene IDBG-12777 (PALM)
Protein Structure
UniProt Annotation
Function Involved in plasma membrane dynamics and cell process formation. Isoform 1 and isoform 2 are necessary for axonal and dendritic filopodia induction, for dendritic spine maturation and synapse formation in a palmitoylation-dependent manner. {ECO:0000269PubMed:14978216}.
Subcellular Localization Cell membrane {ECO:0000269PubMed:14978216}; Lipid-anchor {ECO:0000269PubMed:14978216}; Cytoplasmic side {ECO:0000269PubMed:14978216}. Cell projection, filopodium membrane {ECO:0000269PubMed:14978216}; Lipid-anchor {ECO:0000269PubMed:14978216}. Cell projection, axon {ECO:0000250}. Cell projection, dendrite {ECO:0000250}. Cell projection, dendritic spine {ECO:0000250}. Basolateral cell membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}. Apicolateral cell membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}. Note=Translocation to the plasma membrane is enhanced upon stimulation of neuronal activity.
Disease Associations
Tissue Specificity Widely expressed with highest expression in brain and testis and intermediate expression in heart and adrenal gland.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0006928 cellular component movement
GO:0007194 negative regulation of adenylate cyclase activity
GO:0008360 regulation of cell shape
GO:0051491 positive regulation of filopodium assembly
GO:0060160 negative regulation of dopamine receptor signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016023 cytoplasmic membrane-bounded vesicle
GO:0016323 basolateral plasma membrane
GO:0016327 apicolateral plasma membrane
GO:0030424 axon
GO:0031527 filopodium membrane
Protein Structure and Domains
PDB ID
InterPro IPR004965 Paralemmin
PFAM PF03285
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O75781
PhosphoSite PhosphoSite-O75781
TrEMBL A0A024R207
UniProt Splice Variant
Entrez Gene 5064
UniGene Hs.631841
RefSeq NP_001035224
HUGO HGNC:8594
OMIM 608134
CCDS CCDS32858
HPRD 09734
IMGT
EMBL AC004030 AC005763 BC032449 CH471242 D87460 Y14770 Y16270 Y16271 Y16272 Y16273 Y16274 Y16275 Y16276 Y16277 Y16278
GenPept AAC62429 AAH32449 BAA13400 CAA76151 CAA76152 CAB37400 CAB37401 EAW61163 EAW61164

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca