Version 5.4
Mus musculus Gene: Calcr
Summary
InnateDB Gene IDBG-127859.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Calcr
Gene Name calcitonin receptor
Synonyms Clr
Species Mus musculus
Ensembl Gene ENSMUSG00000023964
Encoded Proteins
IDBP-127861
calcitonin receptor
IDBP-249224
calcitonin receptor
IDBP-622691
calcitonin receptor
IDBP-622695
calcitonin receptor
IDBP-622698
calcitonin receptor
IDBP-622701
calcitonin receptor
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000004948:
This gene encodes a high affinity receptor for the peptide hormone calcitonin and belongs to a subfamily of seven transmembrane-spanning G protein-coupled receptors. The encoded protein is involved in maintaining calcium homeostasis and in regulating osteoclast-mediated bone resorption. Polymorphisms in this gene have been associated with variations in bone mineral density and onset of osteoporosis. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:3685677-3764713
Strand Reverse strand
Band A1
Transcripts
ENSMUST00000075644 ENSMUSP00000075070
ENSMUST00000115622 ENSMUSP00000111285
ENSMUST00000171396 ENSMUSP00000132005
ENSMUST00000171613 ENSMUSP00000130083
ENSMUST00000168592 ENSMUSP00000130243
ENSMUST00000170266 ENSMUSP00000132124
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004888 transmembrane signaling receptor activity
GO:0004930 G-protein coupled receptor activity
GO:0004948 calcitonin receptor activity
GO:0032841 calcitonin binding
Biological Process
GO:0007166 cell surface receptor signaling pathway
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007188 adenylate cyclase-modulating G-protein coupled receptor signaling pathway
GO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0030279 negative regulation of ossification
GO:0030316 osteoclast differentiation
GO:0043488 regulation of mRNA stability
Cellular Component
GO:0001669 acrosomal vesicle
GO:0005886 plasma membrane
GO:0005929 cilium
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030424 axon
GO:0043005 neuron projection
GO:0043025 neuronal cell body
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000004948
View Gene Order
ENSBTAG00000017458
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu04080
Neuroactive ligand-receptor interaction pathway
mmu04380
Osteoclast differentiation pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_19327
G alpha (s) signalling events pathway
REACT_18290
Calcitonin-like ligand receptors pathway
REACT_18372
Class B/2 (Secretin family receptors) pathway
REACT_14797
Signaling by GPCR pathway
REACT_111102
Signal Transduction pathway
REACT_19184
GPCR downstream signaling pathway
REACT_21340
GPCR ligand binding pathway
KEGG
hsa04080
Neuroactive ligand-receptor interaction pathway
hsa04380
Osteoclast differentiation pathway
INOH
PID NCI
Cross-References
SwissProt Q60755
TrEMBL Q924D5 Q924D6
UniProt Splice Variant
Entrez Gene 12311
UniGene Mm.4642
RefSeq NM_001042725 NM_007588 XM_006504972 XM_006504973
OMIM
CCDS CCDS39416 CCDS39417
HPRD
IMGT
MGI ID MGI:101950
MGI Symbol Calcr
EMBL AC066688 AC161368 AF333473 AF333474 AF333475 AF333476 AF333477 AF333478 AF333479 AF333481 AF333482 AF333483 AF333484 AF333485 AK039161 AK133983 AK138275 AK162391 BC119232 BC119272 CH466533 U18542
GenPept AAA69521 AAI19233 AAI19273 AAK56132 AAK56134 BAC30261 BAE21967 BAE23606 BAE36888 EDL13991 EDL13992
RNA Seq Atlas 12311

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca