Version 5.4
Bos taurus Gene: BT.96872
Summary
InnateDB Gene IDBG-629078.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BT.96872
Gene Name calcitonin receptor
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000017458
Encoded Proteins
IDBP-680464
calcitonin receptor
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000004948:
This gene encodes a high affinity receptor for the peptide hormone calcitonin and belongs to a subfamily of seven transmembrane-spanning G protein-coupled receptors. The encoded protein is involved in maintaining calcium homeostasis and in regulating osteoclast-mediated bone resorption. Polymorphisms in this gene have been associated with variations in bone mineral density and onset of osteoporosis. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:10614458-10724579
Strand Reverse strand
Band
Transcripts
ENSBTAT00000023201 ENSBTAP00000023201
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004871 signal transducer activity
GO:0004888 transmembrane signaling receptor activity
GO:0004930 G-protein coupled receptor activity
GO:0004948 calcitonin receptor activity
Biological Process
GO:0007165 signal transduction
GO:0007166 cell surface receptor signaling pathway
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0030279 negative regulation of ossification
GO:0030316 osteoclast differentiation
GO:0043488 regulation of mRNA stability
Cellular Component
GO:0001669 acrosomal vesicle
GO:0005886 plasma membrane
GO:0005929 cilium
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000004948
View Gene Order
ENSMUSG00000023964
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_19327
G alpha (s) signalling events pathway
REACT_18290
Calcitonin-like ligand receptors pathway
REACT_18372
Class B/2 (Secretin family receptors) pathway
REACT_14797
Signaling by GPCR pathway
REACT_111102
Signal Transduction pathway
REACT_19184
GPCR downstream signaling pathway
REACT_21340
GPCR ligand binding pathway
KEGG
hsa04080
Neuroactive ligand-receptor interaction pathway
hsa04380
Osteoclast differentiation pathway
mmu04080
Neuroactive ligand-receptor interaction pathway
mmu04380
Osteoclast differentiation pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL F6Q8B6
UniProt Splice Variant
Entrez Gene 613317
UniGene Bt.96872
RefSeq NM_001076269
HUGO HGNC:1440
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02009771
GenPept
RNA Seq Atlas 613317

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca