Version 5.4
Mus musculus Gene: Epc1
Summary
InnateDB Gene IDBG-127970.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Epc1
Gene Name enhancer of polycomb homolog 1 (Drosophila)
Synonyms 2400007E14Rik; 5730566F07Rik; A930032N02Rik
Species Mus musculus
Ensembl Gene ENSMUSG00000024240
Encoded Proteins
IDBP-127972
enhancer of polycomb homolog 1 (Drosophila)
IDBP-127974
enhancer of polycomb homolog 1 (Drosophila)
IDBP-248695
enhancer of polycomb homolog 1 (Drosophila)
IDBP-540452
enhancer of polycomb homolog 1 (Drosophila)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000120616:
This gene encodes a member of the polycomb group (PcG) family. The encoded protein is a component of the NuA4 histone acetyltransferase complex and can act as both a transcriptional activator and repressor. The encoded protein has been linked to apoptosis, DNA repair, skeletal muscle differentiation, gene silencing, and adult T-cell leukemia/lymphoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 18:6435951-6516108
Strand Reverse strand
Band A1
Transcripts
ENSMUST00000028100 ENSMUSP00000028100
ENSMUST00000050542 ENSMUSP00000060599
ENSMUST00000115870 ENSMUSP00000111536
ENSMUST00000124926 ENSMUSP00000117601
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.
Experimentally validated
Total 10 [view]
Protein-Protein 10 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 17 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004402 histone acetyltransferase activity
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006351 transcription, DNA-templated
GO:0040008 regulation of growth
GO:0043967 histone H4 acetylation
GO:0043968 histone H2A acetylation
GO:0045814 negative regulation of gene expression, epigenetic
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0051155 positive regulation of striated muscle cell differentiation
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0031965 nuclear membrane
GO:0032777 Piccolo NuA4 histone acetyltransferase complex
GO:0035267 NuA4 histone acetyltransferase complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000120616
View Gene Order
ENSBTAG00000001552
Not yet available
Pathways
NETPATH
REACTOME
REACT_218274
Chromatin organization pathway
REACT_226917
HATs acetylate histones pathway
REACT_202766
Chromatin modifying enzymes pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_172610
HATs acetylate histones pathway
REACT_172623
Chromatin organization pathway
REACT_172633
Chromatin modifying enzymes pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.312133 Mm.407405
RefSeq NM_001276350 NM_007935 NM_027497
OMIM
CCDS CCDS29041 CCDS37726 CCDS70868
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca