InnateDB Protein
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IDBP-127972.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Epc1
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Protein Name
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enhancer of polycomb homolog 1 (Drosophila)
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Synonyms
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2400007E14Rik; 5730566F07Rik; A930032N02Rik;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000028100
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InnateDB Gene
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IDBG-127970 (Epc1)
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Protein Structure
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Function |
Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage (By similarity). {ECO:0000250}.
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Subcellular Localization |
Nucleus {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Expressed in adult brain, heart, kidney, liver, lung, skeletal muscle and testis. {ECO:0000269PubMed:9735366}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.
Experimentally validated |
Total |
10
[view]
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Protein-Protein |
10
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
17 [view]
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Molecular Function |
Accession |
GO Term |
GO:0004402
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histone acetyltransferase activity
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Biological Process |
GO:0000122
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negative regulation of transcription from RNA polymerase II promoter
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GO:0006351
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transcription, DNA-templated
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GO:0040008
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regulation of growth
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GO:0043967
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histone H4 acetylation
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GO:0043968
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histone H2A acetylation
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GO:0045814
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negative regulation of gene expression, epigenetic
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GO:0045892
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negative regulation of transcription, DNA-templated
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GO:0045944
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positive regulation of transcription from RNA polymerase II promoter
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GO:0051155
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positive regulation of striated muscle cell differentiation
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Cellular Component |
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PDB ID |
MGI:1278322
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InterPro |
IPR009607
Enhancer of polycomb, C-terminal
IPR019542
Enhancer of polycomb-like, N-terminal
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PFAM |
PF06752
PF10513
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q8C9X6
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PhosphoSite |
PhosphoSite-Q8C9X6
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TrEMBL |
D3Z3Q6
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UniProt Splice Variant |
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Entrez Gene |
13831
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UniGene |
Mm.407405
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RefSeq |
NP_081773
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MGI ID |
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MGI Symbol |
Epc1
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OMIM |
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CCDS |
CCDS29041
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HPRD |
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IMGT |
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EMBL |
AC116580
AC139300
AF079765
AK040254
BC138622
BC138623
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GenPept |
AAC64272
AAI38623
AAI38624
BAC30552
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