Version 5.4
Mus musculus Gene: Card6
Summary
InnateDB Gene IDBG-127983.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Card6
Gene Name caspase recruitment domain family, member 6
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000041849
Encoded Proteins
IDBP-401778
caspase recruitment domain family, member 6
IDBP-534764
caspase recruitment domain family, member 6
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 16418290
[Homo sapiens] A microtubule-interacting protein that positively regulates NF-kappaB activation and modulates function of RIP family members
PMID 18160713
[Homo sapiens] Expression of CARD6 and RIPK2 in bone marrow-derived macrophages is rapidly induced by IFNB1 and IFNG
PMID 12775719
[Homo sapiens] Selectively modulates NF-kappaB activation by RIPK2 and NOD1
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000132357:
This gene encodes a protein that contains a caspase recruitment domain (CARD), an antiparallel six-helical bundle that mediates homotypic protein-protein interactions. The encoded protein is a microtubule-associated protein that has been shown to interact with receptor-interacting protein kinases and positively modulate signal transduction pathways converging on activation of the inducible transcription factor NF-kB. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:5095981-5108539
Strand Reverse strand
Band A1
Transcripts
ENSMUST00000118365 ENSMUSP00000112833
ENSMUST00000141020 ENSMUSP00000118817
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0005515 protein binding
Biological Process
GO:0042981 regulation of apoptotic process
GO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling
Cellular Component
GO:0005622 intracellular
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000132357
View Gene Order
ENSBTAG00000014374
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu04621
NOD-like receptor signaling pathway pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa04621
NOD-like receptor signaling pathway pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.31252
RefSeq NM_001163138 XM_006519987 XM_006519988 XM_006519989
OMIM
CCDS CCDS49573
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca