Version 5.4
Bos taurus Gene: CARD6
Summary
InnateDB Gene IDBG-629878.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CARD6
Gene Name caspase recruitment domain-containing protein 6
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000014374
Encoded Proteins
IDBP-681305
caspase recruitment domain family, member 6
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 16418290
[Homo sapiens] A microtubule-interacting protein that positively regulates NF-kappaB activation and modulates function of RIP family members
PMID 18160713
[Homo sapiens] Expression of CARD6 and RIPK2 in bone marrow-derived macrophages is rapidly induced by IFNB1 and IFNG
PMID 12775719
[Homo sapiens] Selectively modulates NF-kappaB activation by RIPK2 and NOD1
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000132357:
This gene encodes a protein that contains a caspase recruitment domain (CARD), an antiparallel six-helical bundle that mediates homotypic protein-protein interactions. The encoded protein is a microtubule-associated protein that has been shown to interact with receptor-interacting protein kinases and positively modulate signal transduction pathways converging on activation of the inducible transcription factor NF-kB. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 20:33638644-33653345
Strand Reverse strand
Band
Transcripts
ENSBTAT00000019112 ENSBTAP00000019112
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0042981 regulation of apoptotic process
Cellular Component
GO:0005622 intracellular
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000132357
View Gene Order
ENSMUSG00000041849
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa04621
NOD-like receptor signaling pathway pathway
mmu04621
NOD-like receptor signaling pathway pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Bt.59708
RefSeq NM_001192521 XM_005221547
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca