InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Slc25a13

Summary

InnateDB Gene

IDBG-128223.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Slc25a13

Gene Name

solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 13

Synonyms

AI785475; Ctrn

Species

Mus musculus

Ensembl Gene

ENSMUSG00000015112

Encoded Proteins

IDBP-128225

solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 13

IDBP-788306

solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 13

IDBP-788307

solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 13

IDBP-788308

solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 13

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000004864:
This gene is a member of the mitochondrial carrier family. The encoded protein contains four EF-hand Ca(2+) binding motifs in the N-terminal domain, and localizes to mitochondria. The protein catalyzes the exchange of aspartate for glutamate and a proton across the inner mitochondrial membrane, and is stimulated by calcium on the external side of the inner mitochondrial membrane. Mutations in this gene result in citrullinemia, type II. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:6041218-6217173

Strand

Reverse strand

Band

Transcripts

ENSMUST00000015256	ENSMUSP00000015256
ENSMUST00000169197
ENSMUST00000179756
ENSMUST00000177698
ENSMUST00000177805
ENSMUST00000188414	ENSMUSP00000139571
ENSMUST00000188130	ENSMUSP00000140876
ENSMUST00000189611	ENSMUSP00000139561

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 20 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	20 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005313	L-glutamate transmembrane transporter activity
GO:0005509	calcium ion binding
GO:0015183	L-aspartate transmembrane transporter activity

Biological Process

GO:0006754	ATP biosynthetic process
GO:0015810	aspartate transport
GO:0015813	L-glutamate transport
GO:0043490	malate-aspartate shuttle
GO:0045333	cellular respiration
GO:0051592	response to calcium ion
GO:0055085	transmembrane transport