Version 5.4
Mus musculus Gene: Shfm1
Summary
InnateDB Gene IDBG-128235.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Shfm1
Gene Name split hand/foot malformation (ectrodactyly) type 1
Synonyms DSS1; Shfdg1; Shfg
Species Mus musculus
Ensembl Gene ENSMUSG00000042541
Encoded Proteins
IDBP-128237
split hand/foot malformation (ectrodactyly) type 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000127922:
The product of this gene has been localized within the split hand/split foot malformation locus SHFM1 at chromosome 7. It has been proposed to be a candidate gene for the autosomal dominant form of the heterogeneous limb developmental disorder split hand/split foot malformation type 1. In addition, it has been shown to directly interact with BRCA2. It also may play a role in the completion of the cell cycle. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:6557294-6578658
Strand Reverse strand
Band A1
Transcripts
ENSMUST00000041111 ENSMUSP00000040741
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 42 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 42 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008233 peptidase activity
Biological Process
GO:0000724 double-strand break repair via homologous recombination
GO:0006508 proteolysis
Cellular Component
GO:0000502 proteasome complex
GO:0005634 nucleus
GO:0032039 integrator complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000127922
View Gene Order
ENSBTAG00000034496
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu03050
Proteasome pathway
mmu03440
Homologous recombination pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa03050
Proteasome pathway
hsa03440
Homologous recombination pathway
INOH
PID NCI
Cross-References
SwissProt P60897
TrEMBL Q3TV35
UniProt Splice Variant
Entrez Gene 20422
UniGene Mm.2469
RefSeq NM_009169
OMIM
CCDS CCDS39422
HPRD
IMGT
MGI ID MGI:109238
MGI Symbol Shfm1
EMBL AK160432 AK161690 AK167914 BC023490 BC058117 CH466533 U41626
GenPept AAA91180 AAH23490 AAH58117 BAE35785 BAE36534 BAE39921 EDL13957
RNA Seq Atlas 20422

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca