InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Shfm1

Summary

InnateDB Protein

IDBP-128237.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Shfm1

Protein Name

split hand/foot malformation (ectrodactyly) type 1

Synonyms

DSS1; Shfdg1; Shfg;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000040741

InnateDB Gene

IDBG-128235 (Shfm1)

Protein Structure

UniProt Annotation

Function

Subunit of the 26S proteasome which plays a role in ubiquitin-dependent proteolysis. {ECO:0000250}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 42 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	42 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008233	peptidase activity

Biological Process

GO:0000724	double-strand break repair via homologous recombination
GO:0006508	proteolysis

Cellular Component

GO:0000502	proteasome complex
GO:0005634	nucleus
GO:0032039	integrator complex

Protein Structure and Domains

PDB ID

MGI:109238

InterPro

IPR007834 DSS1/SEM1

PFAM

PF05160

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P60897

PhosphoSite

PhosphoSite-

TrEMBL

Q3TV35

UniProt Splice Variant

Entrez Gene

20422

UniGene

Mm.2469

RefSeq

NP_033195

MGI ID

MGI Symbol

Shfm1

OMIM

CCDS

CCDS39422

HPRD

IMGT

EMBL

AK160432 AK161690 AK167914 BC023490 BC058117 CH466533 U41626

GenPept

AAA91180 AAH23490 AAH58117 BAE35785 BAE36534 BAE39921 EDL13957