InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Tac1

Summary

InnateDB Gene

IDBG-128294.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tac1

Gene Name

tachykinin 1

Synonyms

4930528L02Rik; NK-1; NK1; Nkna; PPT-A; PPTA; SP

Species

Mus musculus

Ensembl Gene

ENSMUSG00000061762

Encoded Proteins

IDBP-128296

tachykinin 1

IDBP-788758

tachykinin 1

IDBP-788759

tachykinin 1

IDBP-788760

tachykinin 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000006128:
This gene encodes four products of the tachykinin peptide hormone family, substance P and neurokinin A, as well as the related peptides, neuropeptide K and neuropeptide gamma. These hormones are thought to function as neurotransmitters which interact with nerve receptors and smooth muscle cells. They are known to induce behavioral responses and function as vasodilators and secretagogues. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:7554879-7565834

Strand

Forward strand

Band

Transcripts

ENSMUST00000090679	ENSMUSP00000088175
ENSMUST00000185187	ENSMUSP00000139347
ENSMUST00000184986	ENSMUSP00000138818
ENSMUST00000185130	ENSMUSP00000139032
ENSMUST00000184481

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0031835	substance P receptor binding

Biological Process

GO:0002675	positive regulation of acute inflammatory response
GO:0006954	inflammatory response
GO:0007204	positive regulation of cytosolic calcium ion concentration
GO:0007217	tachykinin receptor signaling pathway
GO:0007218	neuropeptide signaling pathway
GO:0007268	synaptic transmission
GO:0007616	long-term memory
GO:0008217	regulation of blood pressure
GO:0008306	associative learning
GO:0009725	response to hormone
GO:0010459	negative regulation of heart rate
GO:0010634	positive regulation of epithelial cell migration
GO:0019233	sensory perception of pain
GO:0032224	positive regulation of synaptic transmission, cholinergic
GO:0032230	positive regulation of synaptic transmission, GABAergic
GO:0032496	response to lipopolysaccharide
GO:0035815	positive regulation of renal sodium excretion
GO:0043278	response to morphine
GO:0045760	positive regulation of action potential
GO:0045778	positive regulation of ossification
GO:0046878	positive regulation of saliva secretion
GO:0048265	response to pain
GO:0050671	positive regulation of lymphocyte proliferation
GO:0051496	positive regulation of stress fiber assembly
GO:2000854	positive regulation of corticosterone secretion