Version 5.4
Homo sapiens Gene: TAC1
Summary
InnateDB Gene IDBG-28145.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TAC1
Gene Name tachykinin, precursor 1
Synonyms Hs.2563; NK2; NKNA; NPK; TAC2
Species Homo sapiens
Ensembl Gene ENSG00000006128
Encoded Proteins
IDBP-28147
tachykinin, precursor 1
IDBP-28149
tachykinin, precursor 1
IDBP-28151
tachykinin, precursor 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes four products of the tachykinin peptide hormone family, substance P and neurokinin A, as well as the related peptides, neuropeptide K and neuropeptide gamma. These hormones are thought to function as neurotransmitters which interact with nerve receptors and smooth muscle cells. They are known to induce behavioral responses and function as vasodilators and secretagogues. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:97731908-97740472
Strand Forward strand
Band q21.3
Transcripts
ENST00000319273 ENSP00000321106
ENST00000346867 ENSP00000289574
ENST00000350485 ENSP00000289576
ENST00000495916
ENST00000491437
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
Experimentally validated
Total 18 [view]
Protein-Protein 18 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0031835 substance P receptor binding
Biological Process
GO:0002675 positive regulation of acute inflammatory response
GO:0006954 inflammatory response
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0007217 tachykinin receptor signaling pathway
GO:0007218 neuropeptide signaling pathway
GO:0007267 cell-cell signaling
GO:0007268 synaptic transmission
GO:0007320 insemination
GO:0007616 long-term memory
GO:0008217 regulation of blood pressure
GO:0008306 associative learning
GO:0009582 detection of abiotic stimulus
GO:0009725 response to hormone
GO:0010459 negative regulation of heart rate
GO:0010634 positive regulation of epithelial cell migration
GO:0019233 sensory perception of pain
GO:0032224 positive regulation of synaptic transmission, cholinergic
GO:0032230 positive regulation of synaptic transmission, GABAergic
GO:0032496 response to lipopolysaccharide
GO:0035815 positive regulation of renal sodium excretion
GO:0043278 response to morphine
GO:0045760 positive regulation of action potential
GO:0045778 positive regulation of ossification
GO:0046878 positive regulation of saliva secretion
GO:0048265 response to pain
GO:0050671 positive regulation of lymphocyte proliferation
GO:0051496 positive regulation of stress fiber assembly
GO:2000854 positive regulation of corticosterone secretion
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005886 plasma membrane
GO:0030424 axon
GO:0043025 neuronal cell body
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000061762
View Gene Order
ENSBTAG00000015356
Not yet available
Pathways
NETPATH
REACTOME
REACT_18283
G alpha (q) signalling events pathway
REACT_120966
Gastrin-CREB signalling pathway via PKC and MAPK pathway
REACT_16963
Tachykinin receptors bind tachykinins pathway
REACT_14819
Peptide ligand-binding receptors pathway
REACT_14828
Class A/1 (Rhodopsin-like receptors) pathway
REACT_14797
Signaling by GPCR pathway
REACT_111102
Signal Transduction pathway
REACT_19184
GPCR downstream signaling pathway
REACT_21340
GPCR ligand binding pathway
KEGG
INOH
INOH website
GPCR signaling pathway
PID NCI
Cross-References
SwissProt P20366
TrEMBL Q9Y494
UniProt Splice Variant
Entrez Gene 6863
UniGene Hs.2563 Hs.601895
RefSeq NM_003182 NM_013996 NM_013997
HUGO HGNC:11517
OMIM 162320
CCDS CCDS5649 CCDS5650 CCDS5651
HPRD
IMGT
EMBL AC004140 AF050655 AF050656 AF050657 AF050658 AK222957 BC018047 CH236949 CH471091 CR407602 CR541730 M68906 M68907 U37529 X54469
GenPept AAA60159 AAA60160 AAA79195 AAC15701 AAC15702 AAC15703 AAC15704 AAH18047 AAQ96888 AAQ96889 AAQ96890 AAQ96891 BAD96677 CAA38351 CAG28529 CAG46531 EAL24116 EAL24117 EAL24118 EAL24119 EAW76734 EAW76735 EAW76736 EAW76737
RNA Seq Atlas 6863

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca