InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: GNRH1

Summary

InnateDB Gene

IDBG-12832.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GNRH1

Gene Name

gonadotropin-releasing hormone 1 (luteinizing-releasing hormone)

Synonyms

GNRH; GRH; HH12; LHRH; LNRH

Species

Homo sapiens

Ensembl Gene

ENSG00000147437

Encoded Proteins

IDBP-12834

gonadotropin-releasing hormone 1 (luteinizing-releasing hormone)

IDBP-364439

gonadotropin-releasing hormone 1 (luteinizing-releasing hormone)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is secreted and then cleaved to form the 10 aa luteinizing hormone-releasing hormone (LHRH, also known as gonadoliberin-1), and prolactin release-inhibiting factor (also known as GnRH-associated peptide 1). LHRH stimulates the release of luteinizing and follicle stimulating hormones, which are important for reproduction. Mutation in this gene are associated with hypogonadotropic hypogonadism. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Jul 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 8:25419260-25424654

Strand

Reverse strand

Band

p21.2

Transcripts

ENST00000276414	ENSP00000276414
ENST00000421054	ENSP00000391280

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005179	hormone activity
GO:0005183	gonadotropin hormone-releasing hormone activity

Biological Process

GO:0007165	signal transduction
GO:0007267	cell-cell signaling
GO:0007275	multicellular organismal development
GO:0007565	female pregnancy
GO:0008285	negative regulation of cell proliferation
GO:0010468	regulation of gene expression
GO:0031960	response to corticosteroid
GO:0042698	ovulation cycle
GO:0043066	negative regulation of apoptotic process
GO:0045471	response to ethanol
GO:0048545	response to steroid hormone
GO:2000354	regulation of ovarian follicle development
GO:2001223	negative regulation of neuron migration