Version 5.4
Mus musculus Gene: Akr1c18
Summary
InnateDB Gene IDBG-128569.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Akr1c18
Gene Name aldo-keto reductase family 1, member C18
Synonyms AW146047
Species Mus musculus
Ensembl Gene ENSMUSG00000021214
Encoded Proteins
IDBP-128571
aldo-keto reductase family 1, member C18
IDBP-259696
aldo-keto reductase family 1, member C18
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 13:4132615-4150654
Strand Reverse strand
Band A1
Transcripts
ENSMUST00000021635 ENSMUSP00000021635
ENSMUST00000110704 ENSMUSP00000106332
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0047006 17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity
Biological Process
GO:0006709 progesterone catabolic process
GO:0007567 parturition
GO:0042448 progesterone metabolic process
GO:0050810 regulation of steroid biosynthetic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005829 cytosol
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
REACT_189085
Disease pathway
REACT_198569
Retinoid metabolism and transport pathway
REACT_210229
Synthesis of bile acids and bile salts via 24-hydroxycholesterol pathway
REACT_188937
Metabolism pathway
REACT_232291
Metabolism of lipids and lipoproteins pathway
REACT_207530
Synthesis of bile acids and bile salts pathway
REACT_203193
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol pathway
REACT_188260
Visual phototransduction pathway
REACT_226440
Synthesis of bile acids and bile salts via 27-hydroxycholesterol pathway
REACT_188257
Signal Transduction pathway
REACT_188255
Diseases associated with visual transduction pathway
REACT_229469
Bile acid and bile salt metabolism pathway
REACT_188623
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) pathway
REACT_188625
Arachidonic acid metabolism pathway
KEGG
mmu00140
Steroid hormone biosynthesis pathway
INOH
PID NCI
Cross-References
SwissProt Q8K023
TrEMBL
UniProt Splice Variant
Entrez Gene 105349
UniGene Mm.41337
RefSeq NM_134066
OMIM
CCDS CCDS26219
HPRD
IMGT
MGI ID MGI:2145420
MGI Symbol Akr1c18
EMBL AB059565 BC034259
GenPept AAH34259 BAB40958
RNA Seq Atlas 105349

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca