InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Akr1c18

Summary

InnateDB Protein

IDBP-128571.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Akr1c18

Protein Name

aldo-keto reductase family 1, member C18

Synonyms

AW146047;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000021635

InnateDB Gene

IDBG-128569 (Akr1c18)

Protein Structure

UniProt Annotation

Function

Catalyzes the conversion of progesterone into 20-alpha- dihydroprogesterone (20 alpha-OHP).

Subcellular Localization

Cytoplasm {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0047006	17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity

Biological Process

GO:0006709	progesterone catabolic process
GO:0007567	parturition
GO:0042448	progesterone metabolic process
GO:0050810	regulation of steroid biosynthetic process
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005829

cytosol

Protein Structure and Domains

PDB ID

MGI:2145420

InterPro

IPR020471 Aldo/keto reductase subgroup
IPR023210 NADP-dependent oxidoreductase domain

PFAM

PF00248

PRINTS

PR00069

PIRSF

PIRSF000097

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8K023

PhosphoSite

PhosphoSite-Q8K023

TrEMBL

Q3U538

UniProt Splice Variant

Entrez Gene

105349

UniGene

Mm.41337

RefSeq

NP_598827

MGI ID

MGI Symbol

Akr1c18

OMIM

CCDS

CCDS26219

HPRD

IMGT

EMBL

AB059565 AK153898 BC034259 CH466588

GenPept

AAH34259 BAB40958 BAE32242 EDL32238