Version 5.4
Mus musculus Gene: Cables1
Summary
InnateDB Gene IDBG-128652.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cables1
Gene Name CDK5 and Abl enzyme substrate 1
Synonyms Cables; ik3-1
Species Mus musculus
Ensembl Gene ENSMUSG00000040957
Encoded Proteins
IDBP-128654
CDK5 and Abl enzyme substrate 1
IDBP-621319
CDK5 and Abl enzyme substrate 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000134508:
This gene encodes a protein involved in regulation of the cell cycle through interactions with several cyclin-dependent kinases. One study (PMID: 16177568) reported aberrant splicing of transcripts from this gene which results in removal of the cyclin binding domain only in human cancer cells, and reduction in gene expression was shown in colorectal cancers (PMID: 17982127).Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 18:11839220-11945627
Strand Forward strand
Band A1
Transcripts
ENSMUST00000046948 ENSMUSP00000040639
ENSMUST00000171109 ENSMUSP00000129463
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity
Biological Process
GO:0000082 G1/S transition of mitotic cell cycle
GO:0007399 nervous system development
GO:0045859 regulation of protein kinase activity
GO:0051301 cell division
GO:0051302 regulation of cell division
GO:0051726 regulation of cell cycle
Cellular Component
GO:0005654 nucleoplasm
GO:0005829 cytosol
GO:0030426 growth cone
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000134508
View Gene Order
ENSBTAG00000008705
Not yet available
Pathways
NETPATH
REACTOME
REACT_224553
Hemostasis pathway
REACT_198649
Factors involved in megakaryocyte development and platelet production pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_24970
Factors involved in megakaryocyte development and platelet production pathway
REACT_604
Hemostasis pathway
KEGG
INOH
PID NCI
tap63pathway
Validated transcriptional targets of TAp63 isoforms
ajdiss_2pathway
Posttranslational regulation of adherens junction stability and dissassembly
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.406946 Mm.40717
RefSeq NM_001146287 NM_022021
OMIM
CCDS CCDS29061 CCDS50220
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca