InnateDB Protein
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IDBP-128654.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Cables1
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Protein Name
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CDK5 and Abl enzyme substrate 1
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Synonyms
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Cables; ik3-1;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000040639
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InnateDB Gene
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IDBG-128652 (Cables1)
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Protein Structure
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Function |
Cyclin-dependent kinase binding protein. Enhances cyclin-dependent kinase tyrosine phosphorylation by nonreceptor tyrosine kinases, such as that of CDK5 by activated ABL1, which leads to increased CDK5 activity and is critical for neuronal development, and that of CDK2 by WEE1, which leads to decreased CDK2 activity and growth inhibition. Positively affects neuronal outgrowth. Plays a role as a regulator for p53/p73-induced cell death (By similarity). {ECO:0000250}.
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Subcellular Localization |
Nucleus. Cytoplasm. Cell projection, growth cone. Note=Located in the cell body and proximal region of the developing axonal shaft of immature neurons. Located in axonal growth cone, but not in the distal part of the axon shaft or in dendritic growth cone of mature neurons.
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Disease Associations |
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Tissue Specificity |
Ubiquitous. Expressed in postnatal day 1 (P1), in postmitotic neurons of the subplate, cortex (V/VI) and marginal zone; in postnatal day 7 (P7), in all layers of the cerebral cortex and in the CA1 and CA2 regions of the hippocampus (at protein level). Highly expressed in brain, kidney, liver and lung. {ECO:0000269PubMed:10873625, ECO:0000269PubMed:10896159}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated |
Total |
6
[view]
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Protein-Protein |
6
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
4 [view]
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Molecular Function |
Accession |
GO Term |
GO:0005515
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protein binding
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GO:0016538
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cyclin-dependent protein serine/threonine kinase regulator activity
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1927065
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InterPro |
IPR006671
Cyclin, N-terminal
IPR012388
Cdk5/c-Abl linker protein Cables
IPR013763
Cyclin-like
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PFAM |
PF00134
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PRINTS |
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PIRSF |
PIRSF025798
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SMART |
SM00385
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TIGRFAMs |
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Modification |
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SwissProt |
Q9ESJ1
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PhosphoSite |
PhosphoSite-Q9ESJ1
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
63955
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UniGene |
Mm.40717
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RefSeq |
NP_071304
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MGI ID |
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MGI Symbol |
Cables1
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OMIM |
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CCDS |
CCDS29061
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HPRD |
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IMGT |
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EMBL |
AC100751
AC132941
AF133208
AF328140
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GenPept |
AAG33933
AAG42916
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