Version 5.4
Mus musculus Gene: Akr1c6
Summary
InnateDB Gene IDBG-128689.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Akr1c6
Gene Name aldo-keto reductase family 1, member C6
Synonyms 3alpha-HSD; Akr1c1; Hsd17b5
Species Mus musculus
Ensembl Gene ENSMUSG00000021210
Encoded Proteins
IDBP-128691
aldo-keto reductase family 1, member C6
IDBP-537904
aldo-keto reductase family 1, member C6
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 13:4434306-4457530
Strand Forward strand
Band A1
Transcripts
ENSMUST00000021630 ENSMUSP00000021630
ENSMUST00000128695
ENSMUST00000156277 ENSMUSP00000117624
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004033 aldo-keto reductase (NADP) activity
GO:0004303 estradiol 17-beta-dehydrogenase activity
Biological Process
GO:0006694 steroid biosynthetic process
GO:0008202 steroid metabolic process
GO:0055114 oxidation-reduction process
Cellular Component
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
REACT_189085
Disease pathway
REACT_198569
Retinoid metabolism and transport pathway
REACT_210229
Synthesis of bile acids and bile salts via 24-hydroxycholesterol pathway
REACT_188937
Metabolism pathway
REACT_232291
Metabolism of lipids and lipoproteins pathway
REACT_207530
Synthesis of bile acids and bile salts pathway
REACT_203193
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol pathway
REACT_188260
Visual phototransduction pathway
REACT_226440
Synthesis of bile acids and bile salts via 27-hydroxycholesterol pathway
REACT_188257
Signal Transduction pathway
REACT_188255
Diseases associated with visual transduction pathway
REACT_229469
Bile acid and bile salt metabolism pathway
REACT_188623
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) pathway
REACT_188625
Arachidonic acid metabolism pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt P70694
TrEMBL D3Z3P8 Q3UEM0
UniProt Splice Variant
Entrez Gene 83702
UniGene Mm.196666
RefSeq NM_030611
OMIM
CCDS CCDS26223
HPRD
IMGT
MGI ID MGI:1933427
MGI Symbol Akr1c6
EMBL AC166056 AF110408 AF110409 AF110410 AF110411 AF110412 AF110413 AF110414 AK149458 BC056643 CH466588 D45850
GenPept AAD41250 AAH56643 BAA08285 BAE28891 EDL32249
RNA Seq Atlas 83702

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca