Version 5.4
Mus musculus Protein: Akr1c6
Summary
InnateDB Protein IDBP-128691.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Akr1c6
Protein Name aldo-keto reductase family 1, member C6
Synonyms 3alpha-HSD; Akr1c1; Hsd17b5;
Species Mus musculus
Ensembl Protein ENSMUSP00000021630
InnateDB Gene IDBG-128689 (Akr1c6)
Protein Structure
UniProt Annotation
Function Active toward androgens, estrogens, and xenobiotic substrates. Also exhibits low 20 alpha-HSD activity. Shows a- stereospecificity in hydrogen transfer between cofactors and substrates (A-specific). Preferentially catalyzes the reduction of 4-androstenedione, 5-alpha-androstane-3,17-dione, androsterone and dehydroepiandrosterone to testosterone, dihydrotestosterone, 5- alpha-androstane-3-alpha,17-beta-diol and 5-androstene-3-beta,17- beta-diol, respectively. {ECO:0000269PubMed:10500239}.
Subcellular Localization
Disease Associations
Tissue Specificity Mainly found in liver. Also expressed weakly in kidney. {ECO:0000269PubMed:10500239}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004033 aldo-keto reductase (NADP) activity
GO:0004303 estradiol 17-beta-dehydrogenase activity
Biological Process
GO:0006694 steroid biosynthetic process
GO:0008202 steroid metabolic process
GO:0055114 oxidation-reduction process
Cellular Component
Protein Structure and Domains
PDB ID MGI:1933427
InterPro IPR020471 Aldo/keto reductase subgroup
IPR023210 NADP-dependent oxidoreductase domain
PFAM PF00248
PRINTS PR00069
PIRSF PIRSF000097
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P70694
PhosphoSite PhosphoSite-P70694
TrEMBL Q3UEM0
UniProt Splice Variant
Entrez Gene 83702
UniGene Mm.196666
RefSeq NP_085114
MGI ID
MGI Symbol Akr1c6
OMIM
CCDS CCDS26223
HPRD
IMGT
EMBL AC166056 AF110408 AF110409 AF110410 AF110411 AF110412 AF110413 AF110414 AK149458 BC056643 CH466588 D45850
GenPept AAD41250 AAH56643 BAA08285 BAE28891 EDL32249

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca