Version 5.4
Mus musculus Gene: Foxp2
Summary
InnateDB Gene IDBG-128800.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Foxp2
Gene Name forkhead box P2
Synonyms 2810043D05Rik; AI449000; CAG-16; D0Kist7
Species Mus musculus
Ensembl Gene ENSMUSG00000029563
Encoded Proteins
IDBP-128802
forkhead box P2
IDBP-249538
forkhead box P2
IDBP-249540
forkhead box P2
IDBP-249542
forkhead box P2
IDBP-249544
forkhead box P2
IDBP-249546
forkhead box P2
IDBP-249548
forkhead box P2
IDBP-401688
forkhead box P2
IDBP-536724
forkhead box P2
IDBP-541218
forkhead box P2
IDBP-535493
forkhead box P2
IDBP-533079
forkhead box P2
IDBP-539587
forkhead box P2
IDBP-542672
forkhead box P2
IDBP-535455
forkhead box P2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000128573:
This gene encodes a member of the forkhead/winged-helix (FOX) family of transcription factors. It is expressed in fetal and adult brain as well as in several other organs such as the lung and gut. The protein product contains a FOX DNA-binding domain and a large polyglutamine tract and is an evolutionarily conserved transcription factor, which may bind directly to approximately 300 to 400 gene promoters in the human genome to regulate the expression of a variety of genes. This gene is required for proper development of speech and language regions of the brain during embryogenesis, and may be involved in a variety of biological pathways and cascades that may ultimately influence language development. Mutations in this gene cause speech-language disorder 1 (SPCH1), also known as autosomal dominant speech and language disorder with orofacial dyspraxia. Multiple alternative transcripts encoding different isoforms have been identified in this gene.[provided by RefSeq, Feb 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:14901349-15441977
Strand Forward strand
Band A1
Transcripts
ENSMUST00000031545 ENSMUSP00000031545
ENSMUST00000115477 ENSMUSP00000111137
ENSMUST00000115475 ENSMUSP00000111135
ENSMUST00000115474 ENSMUSP00000111134
ENSMUST00000115472 ENSMUSP00000111132
ENSMUST00000115470 ENSMUSP00000111130
ENSMUST00000115469 ENSMUSP00000111129
ENSMUST00000118133 ENSMUSP00000113163
ENSMUST00000151060
ENSMUST00000128567 ENSMUSP00000123067
ENSMUST00000138273
ENSMUST00000156883
ENSMUST00000154448 ENSMUSP00000116017
ENSMUST00000137628 ENSMUSP00000116650
ENSMUST00000151301 ENSMUSP00000114735
ENSMUST00000140557 ENSMUSP00000121503
ENSMUST00000131414 ENSMUSP00000123007
ENSMUST00000159788
ENSMUST00000152563 ENSMUSP00000118879
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001078 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0008301 DNA binding, bending
GO:0042803 protein homodimerization activity
GO:0043565 sequence-specific DNA binding
GO:0046872 metal ion binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0002053 positive regulation of mesenchymal cell proliferation
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0007389 pattern specification process
GO:0007519 skeletal muscle tissue development
GO:0009791 post-embryonic development
GO:0021549 cerebellum development
GO:0021757 caudate nucleus development
GO:0021758 putamen development
GO:0021987 cerebral cortex development
GO:0030324 lung development
GO:0040007 growth
GO:0042297 vocal learning
GO:0043010 camera-type eye development
GO:0045892 negative regulation of transcription, DNA-templated
GO:0048286 lung alveolus development
GO:0048745 smooth muscle tissue development
GO:0050679 positive regulation of epithelial cell proliferation
GO:0060013 righting reflex
GO:0060501 positive regulation of epithelial cell proliferation involved in lung morphogenesis
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000128573
View Gene Order
ENSBTAG00000011246
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.332919 Mm.447934
RefSeq NM_001286607 NM_053242 NM_212435
OMIM
CCDS CCDS19918 CCDS71726
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca