InnateDB Protein
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IDBP-249538.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Foxp2
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Protein Name
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forkhead box P2
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Synonyms
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2810043D05Rik; AI449000; CAG-16; D0Kist7;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000111137
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InnateDB Gene
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IDBG-128800 (Foxp2)
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Protein Structure
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Function |
Transcriptional repressor that may play a role in the specification and differentiation of lung epithelium. May also play a role in developing neural, gastrointestinal and cardiovascular tissues. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential. Plays a role in synapse formation by regulating SRPX2 levels. {ECO:0000269PubMed:14701752, ECO:0000269PubMed:24179158}.
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Subcellular Localization |
Nucleus {ECO:0000305}.
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Disease Associations |
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Tissue Specificity |
Highest expression in lung. Lower expression in spleen, skeletal muscle, brain, kidney and small intestine.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Experimentally validated |
Total |
2
[view]
|
Protein-Protein |
2
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
7 [view]
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|
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Molecular Function |
Accession |
GO Term |
GO:0000978
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RNA polymerase II core promoter proximal region sequence-specific DNA binding
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GO:0001078
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RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
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GO:0003677
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DNA binding
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GO:0003682
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chromatin binding
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GO:0003700
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sequence-specific DNA binding transcription factor activity
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GO:0005515
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protein binding
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GO:0008301
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DNA binding, bending
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GO:0042803
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protein homodimerization activity
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GO:0043565
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sequence-specific DNA binding
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GO:0046872
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metal ion binding
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GO:0046982
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protein heterodimerization activity
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:2148705
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InterPro |
IPR001766
Transcription factor, fork head
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PFAM |
PF00250
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PRINTS |
PR00053
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PIRSF |
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SMART |
SM00339
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TIGRFAMs |
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Modification |
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SwissProt |
P58463
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PhosphoSite |
PhosphoSite-P58463
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TrEMBL |
D3Z7E9
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UniProt Splice Variant |
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Entrez Gene |
114142
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UniGene |
Mm.447934
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RefSeq |
NP_444472
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MGI ID |
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MGI Symbol |
Foxp2
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OMIM |
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CCDS |
CCDS19918
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HPRD |
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IMGT |
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EMBL |
AC122816
AC127320
AC147053
AC150746
AC163724
AF339106
AK082361
AY079003
BC058960
BC062926
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GenPept |
AAH58960
AAH62926
AAK69651
AAL85482
BAC38477
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