Version 5.4
Mus musculus Gene: Car8
Summary
InnateDB Gene IDBG-128812.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Car8
Gene Name carbonic anhydrase 8
Synonyms AW546993; Ca8; Cals; Cals1; Carp; wdl
Species Mus musculus
Ensembl Gene ENSMUSG00000041261
Encoded Proteins
IDBP-128816
carbonic anhydrase 8
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000178538:
The protein encoded by this gene was initially named CA-related protein because of sequence similarity to other known carbonic anhydrase genes. However, the gene product lacks carbonic anhydrase activity (i.e., the reversible hydration of carbon dioxide). The gene product continues to carry a carbonic anhydrase designation based on clear sequence identity to other members of the carbonic anhydrase gene family. The absence of CA8 gene transcription in the cerebellum of the lurcher mutant in mice with a neurologic defect suggests an important role for this acatalytic form. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:8143362-8239041
Strand Reverse strand
Band A1
Transcripts
ENSMUST00000066674 ENSMUSP00000063511
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004089 carbonate dehydratase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
Biological Process
GO:0006730 one-carbon metabolic process
GO:0048015 phosphatidylinositol-mediated signaling
Cellular Component
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000178538
View Gene Order
ENSBTAG00000017529
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu00910
Nitrogen metabolism pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa00910
Nitrogen metabolism pathway
INOH
PID NCI
Cross-References
SwissProt P28651
TrEMBL
UniProt Splice Variant
Entrez Gene 12319
UniGene Mm.119320
RefSeq NM_007592
OMIM
CCDS CCDS17954
HPRD
IMGT
MGI ID MGI:88253
MGI Symbol Car8
EMBL AK004896 BC010773 X61397
GenPept AAH10773 BAC25100 CAA43668
RNA Seq Atlas 12319

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca