Version 5.4
Mus musculus Gene: Mdfic
Summary
InnateDB Gene IDBG-128864.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Mdfic
Gene Name MyoD family inhibitor domain containing
Synonyms Kdt1; Mdfid
Species Mus musculus
Ensembl Gene ENSMUSG00000041390
Encoded Proteins
IDBP-128868
MyoD family inhibitor domain containing
IDBP-401684
MyoD family inhibitor domain containing
IDBP-541502
MyoD family inhibitor domain containing
IDBP-789104
MyoD family inhibitor domain containing
IDBP-789106
MyoD family inhibitor domain containing
IDBP-789102
MyoD family inhibitor domain containing
IDBP-789108
MyoD family inhibitor domain containing
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene product is a member of a family of proteins characterized by a specific cysteine-rich C-terminal domain, which is involved in transcriptional regulation of viral genome expression. Alternative translation initiation from an upstream non-AUG (GUG), and an in-frame, downstream AUG codon, results in the production of two isoforms, which in human have been shown to have different subcellular localization. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:15720661-15802169
Strand Forward strand
Band A1
Transcripts
ENSMUST00000101663 ENSMUSP00000099186
ENSMUST00000120512 ENSMUSP00000113050
ENSMUST00000140516 ENSMUSP00000117664
ENSMUST00000125326 ENSMUSP00000139704
ENSMUST00000128849 ENSMUSP00000140800
ENSMUST00000190255 ENSMUSP00000140641
ENSMUST00000189359 ENSMUSP00000140208
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0030332 cyclin binding
GO:0030957 Tat protein binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0007257 activation of JUN kinase activity
GO:0030111 regulation of Wnt signaling pathway
GO:0042308 negative regulation of protein import into nucleus
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0050434 positive regulation of viral transcription
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000135272
View Gene Order
ENSBTAG00000021543
Not yet available
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
INOH
PID NCI
betacatenin_nuc_pathway
Regulation of nuclear beta catenin signaling and target gene transcription
Cross-References
SwissProt Q8BX65
TrEMBL D6REI0
UniProt Splice Variant
Entrez Gene 16543
UniGene Mm.1314 Mm.403025 Mm.404129 Mm.484260 Mm.484261
RefSeq NM_175088
OMIM
CCDS CCDS19919
HPRD
IMGT
MGI ID MGI:104611
MGI Symbol Mdfic
EMBL AC140265 AC159189 AK048821 AK080178 AK165016 AK172522 BC067006
GenPept AAH67006 BAC33469 BAC37840 BAE38001 BAE43047
RNA Seq Atlas 16543

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca