Version 5.4
Mus musculus Gene: Pfkp
Summary
InnateDB Gene IDBG-128989.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Pfkp
Gene Name phosphofructokinase, platelet
Synonyms 1200015H23Rik; 9330125N24Rik; ATP-PFK; PFK-C; PFK-P
Species Mus musculus
Ensembl Gene ENSMUSG00000021196
Encoded Proteins
IDBP-128991
phosphofructokinase, platelet
IDBP-531822
phosphofructokinase, platelet
IDBP-534040
phosphofructokinase, platelet
IDBP-536418
phosphofructokinase, platelet
IDBP-538934
phosphofructokinase, platelet
IDBP-534985
phosphofructokinase, platelet
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000067057:
The PFKP gene encodes the platelet isoform of phosphofructokinase (PFK) (ATP:D-fructose-6-phosphate-1-phosphotransferase, EC 2.7.1.11). PFK catalyzes the irreversible conversion of fructose-6-phosphate to fructose-1,6-bisphosphate and is a key regulatory enzyme in glycolysis. The PFKP gene, which maps to chromosome 10p, is also expressed in fibroblasts. See also the muscle (PFKM; MIM 610681) and liver (PFKL; MIM 171860) isoforms of phosphofructokinase, which map to chromosomes 12q13 and 21q22, respectively. Vora (1981) [PubMed 6451249] determined that full tetrameric phophofructokinase enzyme expressed in platelets can be composed of subunits P4, P3L, and P2L2.[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 13:6579768-6648777
Strand Reverse strand
Band A1
Transcripts
ENSMUST00000021614 ENSMUSP00000021614
ENSMUST00000131648
ENSMUST00000138703 ENSMUSP00000117030
ENSMUST00000142972 ENSMUSP00000114439
ENSMUST00000154100 ENSMUSP00000116523
ENSMUST00000133041 ENSMUSP00000123662
ENSMUST00000142372
ENSMUST00000151894
ENSMUST00000144053
ENSMUST00000148999
ENSMUST00000135761
ENSMUST00000137327
ENSMUST00000136585 ENSMUSP00000115313
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 32 interaction(s) predicted by orthology.
Experimentally validated
Total 9 [view]
Protein-Protein 8 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 32 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003872 6-phosphofructokinase activity
GO:0005524 ATP binding
GO:0032403 protein complex binding
GO:0046872 metal ion binding
Biological Process
GO:0006002 fructose 6-phosphate metabolic process
GO:0006096 glycolytic process
GO:0046835 carbohydrate phosphorylation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005945 6-phosphofructokinase complex
GO:0016020 membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000067057
View Gene Order
ENSBTAG00000002683
Not yet available
Pathways
NETPATH
REACTOME
REACT_189085
Disease pathway
REACT_232322
Glycolysis pathway
REACT_261601
Glucose metabolism pathway
REACT_188937
Metabolism pathway
REACT_203949
Glycogen storage diseases pathway
REACT_203841
Myoclonic epilepsy of Lafora pathway
REACT_248571
Metabolism of carbohydrates pathway
KEGG
mmu00030
Pentose phosphate pathway pathway
mmu00051
Fructose and mannose metabolism pathway
mmu00010
Glycolysis / Gluconeogenesis pathway
mmu00052
Galactose metabolism pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_1383
Glycolysis pathway
REACT_200783
Myoclonic epilepsy of Lafora pathway
REACT_474
Metabolism of carbohydrates pathway
REACT_111217
Metabolism pathway
REACT_116125
Disease pathway
REACT_723
Glucose metabolism pathway
REACT_200833
Glycogen storage diseases pathway
KEGG
hsa00052
Galactose metabolism pathway
hsa00010
Glycolysis / Gluconeogenesis pathway
hsa00030
Pentose phosphate pathway pathway
hsa00051
Fructose and mannose metabolism pathway
INOH
INOH website
Glycolysis Gluconeogenesis pathway
INOH website
Pentose phosphate cycle pathway
PID NCI
Cross-References
SwissProt
TrEMBL D3YUA3
UniProt Splice Variant
Entrez Gene 56421
UniGene Mm.406927
RefSeq NM_001291071 NM_019703 XM_006516486 XM_006516489
OMIM
CCDS CCDS26230 CCDS70427
HPRD
IMGT
MGI ID MGI:1891833
MGI Symbol Pfkp
EMBL AC159228
GenPept
RNA Seq Atlas 56421

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca