Version 5.4
Homo sapiens Gene: PFKP
Summary
InnateDB Gene IDBG-45598.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PFKP
Gene Name phosphofructokinase, platelet
Synonyms ATP-PFK; PFK-C; PFK-P; PFKF
Species Homo sapiens
Ensembl Gene ENSG00000067057
Encoded Proteins
IDBP-45602
phosphofructokinase, platelet
IDBP-45606
phosphofructokinase, platelet
IDBP-45608
phosphofructokinase, platelet
IDBP-294440
phosphofructokinase, platelet
IDBP-362310
phosphofructokinase, platelet
IDBP-362314
phosphofructokinase, platelet
IDBP-362317
phosphofructokinase, platelet
IDBP-811389
phosphofructokinase, platelet
IDBP-811312
phosphofructokinase, platelet
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The PFKP gene encodes the platelet isoform of phosphofructokinase (PFK) (ATP:D-fructose-6-phosphate-1-phosphotransferase, EC 2.7.1.11). PFK catalyzes the irreversible conversion of fructose-6-phosphate to fructose-1,6-bisphosphate and is a key regulatory enzyme in glycolysis. The PFKP gene, which maps to chromosome 10p, is also expressed in fibroblasts. See also the muscle (PFKM; MIM 610681) and liver (PFKL; MIM 171860) isoforms of phosphofructokinase, which map to chromosomes 12q13 and 21q22, respectively. Vora (1981) [PubMed 6451249] determined that full tetrameric phophofructokinase enzyme expressed in platelets can be composed of subunits P4, P3L, and P2L2.[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:3066333-3137712
Strand Forward strand
Band p15.2
Transcripts
ENST00000381125 ENSP00000370517
ENST00000381075 ENSP00000370465
ENST00000381072 ENSP00000370462
ENST00000407806 ENSP00000385880
ENST00000421751
ENST00000415005 ENSP00000408858
ENST00000413079 ENSP00000387871
ENST00000433193 ENSP00000410275
ENST00000495715
ENST00000468050 ENSP00000476311
ENST00000460445
ENST00000607886 ENSP00000477128
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 41 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 41 [view]
Protein-Protein 41 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003872 6-phosphofructokinase activity
GO:0005524 ATP binding
GO:0032403 protein complex binding
GO:0046872 metal ion binding
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0006002 fructose 6-phosphate metabolic process
GO:0006006 glucose metabolic process
GO:0006096 glycolytic process
GO:0044281 small molecule metabolic process
GO:0046835 carbohydrate phosphorylation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005945 6-phosphofructokinase complex
GO:0016020 membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000021196
View Gene Order
ENSBTAG00000002683
Not yet available
Pathways
NETPATH
REACTOME
REACT_1383
Glycolysis pathway
REACT_200783
Myoclonic epilepsy of Lafora pathway
REACT_474
Metabolism of carbohydrates pathway
REACT_111217
Metabolism pathway
REACT_116125
Disease pathway
REACT_723
Glucose metabolism pathway
REACT_200833
Glycogen storage diseases pathway
KEGG
hsa00052
Galactose metabolism pathway
hsa00010
Glycolysis / Gluconeogenesis pathway
hsa00030
Pentose phosphate pathway pathway
hsa00051
Fructose and mannose metabolism pathway
INOH
INOH website
Glycolysis Gluconeogenesis pathway
INOH website
Pentose phosphate cycle pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.26010
RefSeq NM_001242339 NM_002627 XM_005252466 XM_005252467
HUGO
OMIM
CCDS CCDS55698 CCDS7059
HPRD 01384
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca