InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Il7r

Summary

InnateDB Gene

IDBG-129135.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Il7r

Gene Name

interleukin 7 receptor

Synonyms

CD127; IL-7Ralpha

Species

Mus musculus

Ensembl Gene

ENSMUSG00000003882

Encoded Proteins

IDBP-129137

interleukin 7 receptor

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 26187413

[Homo sapiens] Differentiation of Type 3 innate lymphoid cells (ILC3) to IL7R(+) ILC1 is reversible whereas IL7R(+) ILC1 can differentiate to ILC3 in the presence of IL2, IL23A, and IL1B dependent on the transcription factor RORC, and this process is enhanced in the presence of retinoic acid.

Entrez Gene

Summary

Interleukin-7 is a glycoptorein involved in the regulation of lymphopoiesis. Response of cells to IL7 is dependent on the presence of the interleukin 7 receptor (IL7R); the active receptor is a alpha/gamma chain heterodimer. The gamma(c) chain, which also associates with the interleukin-2 receptor, serves primarily to activate signal transduction by the IL7R complex, while the alpha chain of IL7R determines specific signaling events through its association with cytoplasmic signaling molecules. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 15:9506161-9529876

Strand

Reverse strand

Band

Transcripts

ENSMUST00000003981

ENSMUSP00000003981

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 99 interaction(s) predicted by orthology.

Experimentally validated
Total	15 [view]
Protein-Protein	6 [view]
Protein-DNA	9 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	99 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004896	cytokine receptor activity
GO:0005515	protein binding

Biological Process

GO:0000902	cell morphogenesis
GO:0001915	negative regulation of T cell mediated cytotoxicity
GO:0002377	immunoglobulin production
GO:0008361	regulation of cell size
GO:0010628	positive regulation of gene expression
GO:0016049	cell growth
GO:0019221	cytokine-mediated signaling pathway
GO:0030217	T cell differentiation
GO:0033089	positive regulation of T cell differentiation in thymus
GO:0042100	B cell proliferation
GO:0048535	lymph node development
GO:0048872	homeostasis of number of cells