Mus musculus Gene: Il7r
Summary
InnateDB Gene IDBG-129135.5
Last Modified 2012-02-14 [Report errors or provide feedback]
Gene Symbol Il7r
Gene Name interleukin 7 receptor
Synonyms CD127; IL-7Ralpha;
Species Mus musculus
Ensembl Gene ENSMUSG00000003882
Encoded Proteins
interleukin 7 receptor
Protein Structure
Entrez Gene
Summary Interleukin-7 is a glycoptorein involved in the regulation of lymphopoiesis. Response of cells to IL7 is dependent on the presence of the interleukin 7 receptor (IL7R); the active receptor is a alpha/gamma chain heterodimer. The gamma(c) chain, which also associates with the interleukin-2 receptor, serves primarily to activate signal transduction by the IL7R complex, while the alpha chain of IL7R determines specific signaling events through its association with cytoplasmic signaling molecules. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:9506161-9529876
Strand Reverse strand
Band A1
Transcripts
ENSMUST00000003981 ENSMUSP00000003981
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 179 interaction(s) predicted by orthology.
Experimentally validated
Total 14 [view]
Protein-Protein 5 [view]
Protein-DNA 9 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 179 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004896 cytokine receptor activity
GO:0005515 protein binding
Biological Process
GO:0000902 cell morphogenesis
GO:0001915 negative regulation of T cell mediated cytotoxicity
GO:0002377 immunoglobulin production
GO:0008361 regulation of cell size
GO:0010628 positive regulation of gene expression
GO:0016049 cell growth
GO:0030217 T cell differentiation
GO:0033089 positive regulation of T cell differentiation in thymus
GO:0042100 B cell proliferation
GO:0048535 lymph node development
GO:0048872 homeostasis of number of cells
Cellular Component
GO:0005886 plasma membrane
GO:0009897 external side of plasma membrane
GO:0016021 integral to membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Interleukin-7 signaling pathway
KEGG
Jak-STAT signaling pathway pathway
Cytokine-cytokine receptor interaction pathway
Hematopoietic cell lineage pathway
Primary immunodeficiency pathway
INOH
JAK STAT pathway and regulation pathway
IL-7 signaling pathway
PID BIOCARTA
Il-7 signal transduction [Biocarta view]
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
KitReceptor pathway
IL-7 pathway
TSLP pathway
REACTOME
Interleukin-7 signaling pathway
KEGG
Cytokine-cytokine receptor interaction pathway
Jak-STAT signaling pathway pathway
Hematopoietic cell lineage pathway
Primary immunodeficiency pathway
INOH
JAK STAT pathway and regulation pathway
IL-7 signaling pathway
PID BIOCARTA
PID NCI
Cross-References
SwissProt P16872
TrEMBL Q3U3Z0 Q8C9W4
UniProt Splice Variant
Entrez Gene 16197
UniGene Mm.389 Mm.413294 Mm.416148
RefSeq NM_008372
OMIM
CCDS CCDS27376
HPRD
IMGT
MGI ID 96562 MGI:96562
MGI Symbol Il7r
EMBL AF078906 AK040364 AK042264 AK154516 CH466581 M29697
GenPept AAA39304 AAF06717 BAC30571 BAC31208 BAE32645 EDL03312
ImmGen Il7r (murine)
RNA Seq Atlas 16197