InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Kcnd2

Summary

InnateDB Gene

IDBG-129406.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Kcnd2

Gene Name

potassium voltage-gated channel, Shal-related family, member 2

Synonyms

AI839615; AW555701; Kv4.2; mKIAA1044; R75121

Species

Mus musculus

Ensembl Gene

ENSMUSG00000060882

Encoded Proteins

IDBP-129408

potassium voltage-gated channel, Shal-related family, member 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000184408:
Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shal-related subfamily, members of which form voltage-activated A-type potassium ion channels and are prominent in the repolarization phase of the action potential. This member mediates a rapidly inactivating, A-type outward potassium current which is not under the control of the N terminus as it is in Shaker channels. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:21215503-21729805

Strand

Forward strand

Band

Transcripts

ENSMUST00000081542

ENSMUSP00000080257

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.

Experimentally validated
Total	9 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	14 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005216	ion channel activity
GO:0005250	A-type (transient outward) potassium channel activity
GO:0005515	protein binding
GO:0046872	metal ion binding

Biological Process

GO:0001508	action potential
GO:0006811	ion transport
GO:0034765	regulation of ion transmembrane transport
GO:0051260	protein homooligomerization
GO:0055085	transmembrane transport
GO:0071805	potassium ion transmembrane transport

Cellular Component

GO:0008076	voltage-gated potassium channel complex
GO:0016020	membrane
GO:0043197	dendritic spine

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000184408

View Gene Order

ENSBTAG00000032077

Not yet available

Pathways

NETPATH

REACTOME

REACT_202800

Potassium Channels pathway

REACT_259290

Neuronal System pathway

REACT_199077

Voltage gated Potassium channels pathway

KEGG

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_75770

Voltage gated Potassium channels pathway

REACT_13685

Neuronal System pathway

REACT_75908

Potassium Channels pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

Q9Z0V2

TrEMBL

UniProt Splice Variant

Entrez Gene

16508

UniGene

Mm.391683 Mm.425316

RefSeq

NM_019697

OMIM

CCDS

CCDS19934

HPRD

IMGT

MGI ID

MGI:102663

MGI Symbol

Kcnd2

EMBL

AB045326 AB093280 AF107780 AK032268 AK032772 BC079667

GenPept

AAD16972 AAH79667 BAA97986 BAC27787 BAC28015 BAC41464

RNA Seq Atlas

16508