InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: KCND2

Summary

InnateDB Gene

IDBG-38060.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

KCND2

Gene Name

potassium voltage-gated channel, Shal-related subfamily, member 2

Synonyms

KV4.2; RK5

Species

Homo sapiens

Ensembl Gene

ENSG00000184408

Encoded Proteins

IDBP-38062

potassium voltage-gated channel, Shal-related subfamily, member 2

IDBP-385777

potassium voltage-gated channel, Shal-related subfamily, member 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shal-related subfamily, members of which form voltage-activated A-type potassium ion channels and are prominent in the repolarization phase of the action potential. This member mediates a rapidly inactivating, A-type outward potassium current which is not under the control of the N terminus as it is in Shaker channels. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:120273668-120750331

Strand

Forward strand

Band

q31.31

Transcripts

ENST00000331113	ENSP00000333496
ENST00000425288	ENSP00000415463
ENST00000473190

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	24 [view]
Protein-Protein	24 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005216	ion channel activity
GO:0005249	voltage-gated potassium channel activity
GO:0005250	A-type (transient outward) potassium channel activity
GO:0005515	protein binding
GO:0046872	metal ion binding

Biological Process

GO:0001508	action potential
GO:0006811	ion transport
GO:0007268	synaptic transmission
GO:0034765	regulation of ion transmembrane transport
GO:0051260	protein homooligomerization
GO:0055085	transmembrane transport
GO:0071805	potassium ion transmembrane transport

Cellular Component

GO:0005886	plasma membrane
GO:0008076	voltage-gated potassium channel complex
GO:0016020	membrane
GO:0043197	dendritic spine

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000060882

View Gene Order

ENSBTAG00000032077

Not yet available

Pathways

NETPATH

REACTOME

REACT_75770

Voltage gated Potassium channels pathway

REACT_13685

Neuronal System pathway

REACT_75908

Potassium Channels pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.654739

RefSeq

NM_012281 XM_005250322

HUGO

OMIM

CCDS

CCDS5776

HPRD

09254

IMGT

EMBL

GenPept

RNA Seq Atlas