Version 5.4
Mus musculus Gene: Dnase1
Summary
InnateDB Gene IDBG-129416.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Dnase1
Gene Name deoxyribonuclease I
Synonyms AI788650; DNaseI; Dnl1
Species Mus musculus
Ensembl Gene ENSMUSG00000005980
Encoded Proteins
IDBP-129418
deoxyribonuclease I
IDBP-401745
deoxyribonuclease I
IDBP-542971
deoxyribonuclease I
IDBP-542972
deoxyribonuclease I
IDBP-707229
IDBP-706387
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000213918:
This gene encodes a member of the DNase family. This protein is stored in the zymogen granules of the nuclear envelope and functions by cleaving DNA in an endonucleolytic manner. At least six autosomal codominant alleles have been characterized, DNASE1*1 through DNASE1*6, and the sequence of DNASE1*2 represented in this record. Mutations in this gene have been associated with systemic lupus erythematosus (SLE), an autoimmune disease. A recombinant form of this protein is used to treat the one of the symptoms of cystic fibrosis by hydrolyzing the extracellular DNA in sputum and reducing its viscosity. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:4036942-4040024
Strand Forward strand
Band A1
Transcripts
ENSMUST00000006136 ENSMUSP00000006136
ENSMUST00000120009 ENSMUSP00000113119
ENSMUST00000137748 ENSMUSP00000119934
ENSMUST00000157044 ENSMUSP00000120642
ENSMUST00000144792
ENSMUST00000125961
ENSMUST00000149670
ENSMUST00000132466
ENSMUST00000175755 ENSMUSP00000135060
ENSMUST00000177337 ENSMUSP00000135442
ENSMUST00000176642
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0004530 deoxyribonuclease I activity
GO:0004536 deoxyribonuclease activity
GO:0005515 protein binding
GO:0016888 endodeoxyribonuclease activity, producing 5'-phosphomonoesters
Biological Process
GO:0000737 DNA catabolic process, endonucleolytic
GO:0006308 DNA catabolic process
GO:0006915 apoptotic process
Cellular Component
GO:0005576 extracellular region
GO:0005635 nuclear envelope
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000213918
View Gene Order
ENSBTAG00000020107
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.440565
RefSeq NM_010061 XM_006521774
OMIM
CCDS CCDS27913
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca