Version 5.4
Mus musculus Protein: Dnase1
Summary
InnateDB Protein IDBP-401745.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Dnase1
Protein Name deoxyribonuclease I
Synonyms AI788650; DNaseI; Dnl1;
Species Mus musculus
Ensembl Protein ENSMUSP00000113119
InnateDB Gene IDBG-129416 (Dnase1)
Protein Structure
UniProt Annotation
Function Among other functions, seems to be involved in cell death by apoptosis. Binds specifically to G-actin and blocks actin polymerization (By similarity). {ECO:0000250}.
Subcellular Localization Secreted {ECO:0000250}. Nucleus envelope {ECO:0000250}. Note=Secretory protein, stored in zymogen granules and found in the nuclear envelope. {ECO:0000250}.
Disease Associations
Tissue Specificity In striated muscle, kidney, intestine, liver, lymphnodes, but not in the heart, spleen or pancreas.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0004530 deoxyribonuclease I activity
GO:0004536 deoxyribonuclease activity
Biological Process
GO:0000737 DNA catabolic process, endonucleolytic
GO:0006308 DNA catabolic process
GO:0006915 apoptotic process
Cellular Component
GO:0005576 extracellular region
GO:0005635 nuclear envelope
Protein Structure and Domains
PDB ID MGI:103157
InterPro IPR005135 Endonuclease/exonuclease/phosphatase
IPR016202 Deoxyribonuclease I
PFAM PF03372
PF14529
PRINTS PR00130
PIRSF PIRSF000988
SMART SM00476
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P49183
PhosphoSite PhosphoSite-P49183
TrEMBL Q712W5
UniProt Splice Variant
Entrez Gene 13419
UniGene Mm.440565
RefSeq XP_006521837
MGI ID
MGI Symbol Dnase1
OMIM
CCDS CCDS27913
HPRD
IMGT
EMBL AC087900 AJ000062 BC115570 BC115571 CH466521 D83038 U00478
GenPept AAA03710 AAI15571 AAI15572 BAA28622 CAA03895 EDK97220 EDK97221 EDK97222

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca