Mus musculus Gene: Adrbk1 | |||||||||||||||||||||||||||||
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Summary | |||||||||||||||||||||||||||||
InnateDB Gene | IDBG-129419.6 | ||||||||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||||||||
Gene Symbol | Adrbk1 | ||||||||||||||||||||||||||||
Gene Name | adrenergic receptor kinase, beta 1 | ||||||||||||||||||||||||||||
Synonyms | Adrbk-1; Bark-1; beta ARK; betaARK1; GRK2 | ||||||||||||||||||||||||||||
Species | Mus musculus | ||||||||||||||||||||||||||||
Ensembl Gene | ENSMUSG00000024858 | ||||||||||||||||||||||||||||
Encoded Proteins |
adrenergic receptor kinase, beta 1
adrenergic receptor kinase, beta 1
adrenergic receptor kinase, beta 1
adrenergic receptor kinase, beta 1
adrenergic receptor kinase, beta 1
adrenergic receptor kinase, beta 1
adrenergic receptor kinase, beta 1
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Protein Structure | |||||||||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||||||||
InnateDB Annotation | |||||||||||||||||||||||||||||
Summary |
Fibrates protect against bacteriaâ?induced sepsis by inhibiting LPSâ?mediated ERK phosphorylation and the expression of Adrbk1 (GRK2), thereby preventing Cxcr2 down-regulation on neutrophils.
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Entrez Gene | |||||||||||||||||||||||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000173020:
The product of this gene phosphorylates the beta-2-adrenergic receptor and appears to mediate agonist-specific desensitization observed at high agonist concentrations. This protein is an ubiquitous cytosolic enzyme that specifically phosphorylates the activated form of the beta-adrenergic and related G-protein-coupled receptors. Abnormal coupling of beta-adrenergic receptor to G protein is involved in the pathogenesis of the failing heart. [provided by RefSeq, Jul 2008] |
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Gene Information | |||||||||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||||||||
Genomic Location | Chromosome 19:4286001-4306222 | ||||||||||||||||||||||||||||
Strand | Reverse strand | ||||||||||||||||||||||||||||
Band | A | ||||||||||||||||||||||||||||
Transcripts | |||||||||||||||||||||||||||||
Interactions | |||||||||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 38 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||||||||||
Species
Homo sapiens
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||||||||
REACTOME |
Innate Immune System pathway
Signaling by ERBB2 pathway
PLCG1 events in ERBB2 signaling pathway
GPCR downstream signaling pathway
Disease pathway
Signaling by GPCR pathway
Ca-dependent events pathway
Signaling by FGFR in disease pathway
Gastrin-CREB signalling pathway via PKC and MAPK pathway
PLC-gamma1 signalling pathway
Immune System pathway
EGFR interacts with phospholipase C-gamma pathway
Downstream signal transduction pathway
Downstream signaling of activated FGFR pathway
CaM pathway pathway
Signaling by EGFR pathway
Phospholipase C-mediated cascade pathway
Signalling by NGF pathway
Signaling by PDGF pathway
DAG and IP3 signaling pathway
NGF signalling via TRKA from the plasma membrane pathway
G alpha (q) signalling events pathway
Opioid Signalling pathway
Calmodulin induced events pathway
Signal Transduction pathway
Signaling by FGFR pathway
PLC beta mediated events pathway
G-protein mediated events pathway
Signaling by EGFR in Cancer pathway
DAP12 interactions pathway
DAP12 signaling pathway
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KEGG |
Chemokine signaling pathway pathway
Endocytosis pathway
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INOH | |||||||||||||||||||||||||||||
PID NCI | |||||||||||||||||||||||||||||
Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||||||||
NETPATH |
EGFR1 pathway
Hedgehog pathway
FSH pathway
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REACTOME |
Calmodulin induced events pathway
CaM pathway pathway
DAG and IP3 signaling pathway
DAP12 signaling pathway
DAP12 interactions pathway
PLC-gamma1 signalling pathway
EGFR interacts with phospholipase C-gamma pathway
Signaling by EGFR pathway
G alpha (q) signalling events pathway
Gastrin-CREB signalling pathway via PKC and MAPK pathway
PLC beta mediated events pathway
Opioid Signalling pathway
PLCG1 events in ERBB2 signaling pathway
Signaling by ERBB2 pathway
Phospholipase C-mediated cascade pathway
Signaling by FGFR pathway
Downstream signal transduction pathway
Signaling by PDGF pathway
Signaling by FGFR in disease pathway
Signalling by NGF pathway
Signaling by EGFR in Cancer pathway
Downstream signaling of activated FGFR pathway
Signaling by GPCR pathway
Innate Immune System pathway
Signal Transduction pathway
GPCR downstream signaling pathway
G-protein mediated events pathway
Immune System pathway
NGF signalling via TRKA from the plasma membrane pathway
Ca-dependent events pathway
Disease pathway
DAP12 interactions pathway
Signaling by EGFR pathway
PLCG1 events in ERBB2 signaling pathway
Gastrin-CREB signalling pathway via PKC and MAPK pathway
Signaling by GPCR pathway
Signaling by PDGF pathway
Calmodulin induced events pathway
DAG and IP3 signaling pathway
PLC-gamma1 signalling pathway
Signaling by FGFR pathway
Immune System pathway
EGFR interacts with phospholipase C-gamma pathway
Signaling by ERBB2 pathway
Signal Transduction pathway
Signaling by EGFR in Cancer pathway
G-protein mediated events pathway
NGF signalling via TRKA from the plasma membrane pathway
G alpha (q) signalling events pathway
GPCR downstream signaling pathway
PLC beta mediated events pathway
Downstream signaling of activated FGFR pathway
Signalling by NGF pathway
Phospholipase C-mediated cascade pathway
Downstream signal transduction pathway
Opioid Signalling pathway
Innate Immune System pathway
Ca-dependent events pathway
CaM pathway pathway
DAP12 signaling pathway
Disease pathway
Signaling by FGFR in disease pathway
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KEGG |
Endocytosis pathway
Chemokine signaling pathway pathway
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INOH |
IL-7 signaling pathway
JAK STAT pathway and regulation pathway
EPO signaling pathway pathway
VEGF signaling pathway pathway
Hedgehog signaling pathway pathway
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PID NCI |
CXCR4-mediated signaling events
IL8- and CXCR1-mediated signaling events
Signaling events mediated by HDAC Class II
Signaling events mediated by the Hedgehog family
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Cross-References | |||||||||||||||||||||||||||||
SwissProt | |||||||||||||||||||||||||||||
TrEMBL | |||||||||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||||||||
UniGene | Mm.254144 | ||||||||||||||||||||||||||||
RefSeq | NM_001290818 NM_130863 XM_006531633 | ||||||||||||||||||||||||||||
OMIM | |||||||||||||||||||||||||||||
CCDS | CCDS29426 CCDS70915 | ||||||||||||||||||||||||||||
HPRD | |||||||||||||||||||||||||||||
IMGT | |||||||||||||||||||||||||||||
MGI ID | |||||||||||||||||||||||||||||
MGI Symbol | |||||||||||||||||||||||||||||
EMBL | |||||||||||||||||||||||||||||
GenPept | |||||||||||||||||||||||||||||
RNA Seq Atlas | |||||||||||||||||||||||||||||