InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: ADRBK1

Summary

InnateDB Gene

IDBG-59896.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ADRBK1

Gene Name

adrenergic, beta, receptor kinase 1

Synonyms

BARK1; BETA-ARK1; GRK2

Species

Homo sapiens

Ensembl Gene

ENSG00000173020

Encoded Proteins

IDBP-59898

adrenergic, beta, receptor kinase 1

IDBP-592781

adrenergic, beta, receptor kinase 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 24755316

[Mus musculus] Fibrates protect against bacteria�?�induced sepsis by inhibiting LPS�?�mediated ERK phosphorylation and the expression of Adrbk1 (GRK2), thereby preventing Cxcr2 down-regulation on neutrophils.

Entrez Gene

Summary

The product of this gene phosphorylates the beta-2-adrenergic receptor and appears to mediate agonist-specific desensitization observed at high agonist concentrations. This protein is an ubiquitous cytosolic enzyme that specifically phosphorylates the activated form of the beta-adrenergic and related G-protein-coupled receptors. Abnormal coupling of beta-adrenergic receptor to G protein is involved in the pathogenesis of the failing heart. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:67266410-67286556

Strand

Forward strand

Band

q13.2

Transcripts

ENST00000308595	ENSP00000312262
ENST00000416281
ENST00000526285	ENSP00000434126
ENST00000530291
ENST00000529738
ENST00000533077
ENST00000534651
ENST00000532099
ENST00000526572
ENST00000527176
ENST00000529815
ENST00000531390
ENST00000532611
ENST00000524899

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 58 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Experimentally validated
Total	58 [view]
Protein-Protein	58 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004703	G-protein coupled receptor kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0031694	alpha-2A adrenergic receptor binding
GO:0031755	Edg-2 lysophosphatidic acid receptor binding
GO:0047696	beta-adrenergic receptor kinase activity

Biological Process

GO:0002026	regulation of the force of heart contraction
GO:0002029	desensitization of G-protein coupled receptor protein signaling pathway
GO:0003108	negative regulation of the force of heart contraction by chemical signal
GO:0006468	protein phosphorylation
GO:0007165	signal transduction
GO:0007173	epidermal growth factor receptor signaling pathway
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007202	activation of phospholipase C activity
GO:0007213	G-protein coupled acetylcholine receptor signaling pathway
GO:0007217	tachykinin receptor signaling pathway
GO:0007507	heart development
GO:0008277	regulation of G-protein coupled receptor protein signaling pathway
GO:0008543	fibroblast growth factor receptor signaling pathway
GO:0018105	peptidyl-serine phosphorylation
GO:0018107	peptidyl-threonine phosphorylation
GO:0031623	receptor internalization
GO:0033605	positive regulation of catecholamine secretion
GO:0038032	termination of G-protein coupled receptor signaling pathway
GO:0045087	innate immune response
GO:0045988	negative regulation of striated muscle contraction
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0060048	cardiac muscle contraction