InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: E2f6

Summary

InnateDB Gene

IDBG-129453.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

E2f6

Gene Name

E2F transcription factor 6

Synonyms

AI462434; E2F6b; EMA

Species

Mus musculus

Ensembl Gene

ENSMUSG00000057469

Encoded Proteins

IDBP-129455

E2F transcription factor 6

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000169016:
This gene encodes a member of the E2F transcription factor protein family. E2F family members play a crucial role in control of the cell cycle and of the action of tumor suppressor proteins. They are also a target of the transforming proteins of small DNA tumor viruses. Many E2F proteins contain several evolutionarily conserved domains: a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. The encoded protein of this gene is atypical because it lacks the transactivation and tumor suppressor protein association domains. It contains a modular suppression domain and is an inhibitor of E2F-dependent transcription. The protein is part of a multimeric protein complex that contains a histone methyltransferase and the transcription factors Mga and Max. Multiple transcript variants have been reported for this gene, but it has not been clearly demonstrated that they encode valid isoforms. [provided by RefSeq, Jul 2008]
This gene encodes a member of a family of transcription factors that play a crucial role in the control of the cell cycle. The protein encoded by this gene lacks the transactivation and tumor suppressor protein association domains found in other family members, and contains a modular suppression domain that functions in the inhibition of transcription. It interacts in a complex with chromatin modifying factors. There are pseudogenes for this gene on chromosomes 22 and X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 12:16810965-16826743

Strand

Forward strand

Band

A1.1

Transcripts

ENSMUST00000020908

ENSMUSP00000020908

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 28 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	5 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	28 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity

Biological Process

GO:0000083	regulation of transcription involved in G1/S transition of mitotic cell cycle
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated

Cellular Component

GO:0005634	nucleus
GO:0005662	DNA replication factor A complex
GO:0005667	transcription factor complex
GO:0071339	MLL1 complex

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000169016

View Gene Order

ENSBTAG00000048286

Not yet available

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

KEGG

INOH

PID NCI

e2f_pathway

E2F transcription factor network

Cross-References

SwissProt

O54917

TrEMBL

UniProt Splice Variant

Entrez Gene

50496

UniGene

Mm.409839

RefSeq

NM_033270

OMIM

CCDS

CCDS36409

HPRD

IMGT

MGI ID

MGI:1354159

MGI Symbol

E2f6

EMBL

AC157352 AF032131 AF487711

GenPept

AAC53521 AAM45941

RNA Seq Atlas

50496