InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Amacr

Summary

InnateDB Gene

IDBG-129542.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Amacr

Gene Name

alpha-methylacyl-CoA racemase

Synonyms

Macr1

Species

Mus musculus

Ensembl Gene

ENSMUSG00000022244

Encoded Proteins

IDBP-129544

alpha-methylacyl-CoA racemase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000242110:
This gene encodes a racemase. The encoded enzyme interconverts pristanoyl-CoA and C27-bile acylCoAs between their (R)- and (S)-stereoisomers. The conversion to the (S)-stereoisomers is necessary for degradation of these substrates by peroxisomal beta-oxidation. Encoded proteins from this locus localize to both mitochondria and peroxisomes. Mutations in this gene may be associated with adult-onset sensorimotor neuropathy, pigmentary retinopathy, and adrenomyeloneuropathy due to defects in bile acid synthesis. Alternatively spliced transcript variants have been described. Read-through transcription also exists between this gene and the upstream neighboring C1QTNF3 (C1q and tumor necrosis factor related protein 3) gene. [provided by RefSeq, Mar 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 15:10981756-10996624

Strand

Forward strand

Band

Transcripts

ENSMUST00000070877

ENSMUSP00000066915

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0005102	receptor binding
GO:0008111	alpha-methylacyl-CoA racemase activity

Biological Process

GO:0006631	fatty acid metabolic process
GO:0006699	bile acid biosynthetic process
GO:0008152	metabolic process
GO:0008206	bile acid metabolic process
GO:0008300	isoprenoid catabolic process