InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Adamts12

Summary

InnateDB Gene

IDBG-129587.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Adamts12

Gene Name

a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 12

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000047497

Encoded Proteins

IDBP-129589

a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 12

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000151388:
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS-1) motif. Individual members of this family differ in the number of C-terminal TS-1 motifs, and some have unique C-terminal domains. The enzyme encoded by this gene contains eight TS-1 motifs. It may play roles in pulmonary cells during fetal development or in tumor processes through its proteolytic activity or as a molecule potentially involved in regulation of cell adhesion. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 15:11064790-11346867

Strand

Forward strand

Band

Transcripts

ENSMUST00000061318

ENSMUSP00000057796

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004222	metalloendopeptidase activity
GO:0005515	protein binding
GO:0008233	peptidase activity
GO:0008270	zinc ion binding

Biological Process

GO:0006508	proteolysis
GO:0007160	cell-matrix adhesion
GO:0016477	cell migration
GO:0030167	proteoglycan catabolic process
GO:0032331	negative regulation of chondrocyte differentiation
GO:0050727	regulation of inflammatory response
GO:0051603	proteolysis involved in cellular protein catabolic process
GO:0071347	cellular response to interleukin-1
GO:0071356	cellular response to tumor necrosis factor
GO:0071773	cellular response to BMP stimulus
GO:1901509	regulation of endothelial tube morphogenesis
GO:1902203	negative regulation of hepatocyte growth factor receptor signaling pathway
GO:1902548	negative regulation of cellular response to vascular endothelial growth factor stimulus
GO:2001113	negative regulation of cellular response to hepatocyte growth factor stimulus

Cellular Component

GO:0005578	proteinaceous extracellular matrix
GO:0031012	extracellular matrix

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000151388

View Gene Order

ENSBTAG00000012558

Not yet available

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_22161

Post-translational protein modification pathway

REACT_200727

O-linked glycosylation pathway

REACT_17015

Metabolism of proteins pathway

REACT_200626

O-glycosylation of TSR domain-containing proteins pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

Q811B3

TrEMBL

Q8BMS3

UniProt Splice Variant

Entrez Gene

239337

UniGene

Mm.482727

RefSeq

NM_175501

OMIM

CCDS

CCDS27384

HPRD

IMGT

MGI ID

MGI:2146046

MGI Symbol

Adamts12

EMBL

AC102219 AC156609 AC159963 AJ537452 AK028812 AK048612 AK054015

GenPept

BAC26131 BAC33391 BAC35621 CAD60967

RNA Seq Atlas

239337