InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Adamts12

Summary

InnateDB Protein

IDBP-129589.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Adamts12

Protein Name

a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 12

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000057796

InnateDB Gene

IDBG-129587 (Adamts12)

Protein Structure

UniProt Annotation

Function

Metalloprotease that plays a role in the degradation of COMP (By similarity). Cleaves also alpha-2 macroglobulin and aggregan. Has anti-tumorigenic properties (By similarity). {ECO:0000250}.

Subcellular Localization

Secreted, extracellular space, extracellular matrix {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004222	metalloendopeptidase activity
GO:0005515	protein binding
GO:0008233	peptidase activity
GO:0008270	zinc ion binding

Biological Process

GO:0006508	proteolysis
GO:0007160	cell-matrix adhesion
GO:0016477	cell migration
GO:0030167	proteoglycan catabolic process
GO:0032331	negative regulation of chondrocyte differentiation
GO:0050727	regulation of inflammatory response
GO:0051603	proteolysis involved in cellular protein catabolic process
GO:0071347	cellular response to interleukin-1
GO:0071356	cellular response to tumor necrosis factor
GO:0071773	cellular response to BMP stimulus
GO:1901509	regulation of endothelial tube morphogenesis
GO:1902203	negative regulation of hepatocyte growth factor receptor signaling pathway
GO:1902548	negative regulation of cellular response to vascular endothelial growth factor stimulus
GO:2001113	negative regulation of cellular response to hepatocyte growth factor stimulus

Cellular Component

GO:0005578	proteinaceous extracellular matrix
GO:0031012	extracellular matrix

Protein Structure and Domains

PDB ID

MGI:2146046

InterPro

IPR000884 Thrombospondin, type 1 repeat
IPR001590 Peptidase M12B, ADAM/reprolysin
IPR002870 Peptidase M12B, propeptide
IPR010294 ADAM-TS Spacer 1
IPR010909 PLAC
IPR013273 Peptidase M12B, ADAM-TS

PFAM

PF00090
PF01421
PF01562
PF05986
PF08686

PRINTS

PR01857

PIRSF

SMART

SM00209

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt