InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Pdp1

Summary

InnateDB Gene

IDBG-129710.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pdp1

Gene Name

pyruvate dehyrogenase phosphatase catalytic subunit 1

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000049225

Encoded Proteins

IDBP-129712

pyruvate dehyrogenase phosphatase catalytic subunit 1

IDBP-129714

pyruvate dehyrogenase phosphatase catalytic subunit 1

IDBP-264836

pyruvate dehyrogenase phosphatase catalytic subunit 1

IDBP-264838

pyruvate dehyrogenase phosphatase catalytic subunit 1

IDBP-264840

pyruvate dehyrogenase phosphatase catalytic subunit 1

IDBP-264842

pyruvate dehyrogenase phosphatase catalytic subunit 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000164951:
Pyruvate dehydrogenase (E1) is one of the three components (E1, E2, and E3) of the large pyruvate dehydrogenase complex. Pyruvate dehydrogenase kinases catalyze phosphorylation of serine residues of E1 to inactivate the E1 component and inhibit the complex. Pyruvate dehydrogenase phosphatases catalyze the dephosphorylation and activation of the E1 component to reverse the effects of pyruvate dehydrogenase kinases. Pyruvate dehydrogenase phosphatase is a heterodimer consisting of catalytic and regulatory subunits. Two catalytic subunits have been reported; one is predominantly expressed in skeletal muscle and another one is is much more abundant in the liver. The catalytic subunit, encoded by this gene, is the former, and belongs to the protein phosphatase 2C (PP2C) superfamily. Along with the pyruvate dehydrogenase complex and pyruvate dehydrogenase kinases, this enzyme is located in the mitochondrial matrix. Mutation in this gene causes pyruvate dehydrogenase phosphatase deficiency. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Jun 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:11958184-11966452

Strand

Reverse strand

Band

Transcripts

ENSMUST00000056050	ENSMUSP00000050521
ENSMUST00000095144	ENSMUSP00000092766
ENSMUST00000108302	ENSMUSP00000103937
ENSMUST00000108301	ENSMUSP00000103936
ENSMUST00000108299	ENSMUSP00000103934
ENSMUST00000108297	ENSMUSP00000103932

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004722	protein serine/threonine phosphatase activity
GO:0004741	[pyruvate dehydrogenase (lipoamide)] phosphatase activity
GO:0005509	calcium ion binding
GO:0046872	metal ion binding