InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: PDP1

Summary

InnateDB Gene

IDBG-645282.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PDP1

Gene Name

Synonyms

PDP; PPM2C

Species

Bos taurus

Ensembl Gene

ENSBTAG00000000199

Encoded Proteins

IDBP-697982

IDBP-697984

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000164951:
Pyruvate dehydrogenase (E1) is one of the three components (E1, E2, and E3) of the large pyruvate dehydrogenase complex. Pyruvate dehydrogenase kinases catalyze phosphorylation of serine residues of E1 to inactivate the E1 component and inhibit the complex. Pyruvate dehydrogenase phosphatases catalyze the dephosphorylation and activation of the E1 component to reverse the effects of pyruvate dehydrogenase kinases. Pyruvate dehydrogenase phosphatase is a heterodimer consisting of catalytic and regulatory subunits. Two catalytic subunits have been reported; one is predominantly expressed in skeletal muscle and another one is is much more abundant in the liver. The catalytic subunit, encoded by this gene, is the former, and belongs to the protein phosphatase 2C (PP2C) superfamily. Along with the pyruvate dehydrogenase complex and pyruvate dehydrogenase kinases, this enzyme is located in the mitochondrial matrix. Mutation in this gene causes pyruvate dehydrogenase phosphatase deficiency. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Jun 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 14:72678594-72686976

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000000233	ENSBTAP00000000233
ENSBTAT00000045859	ENSBTAP00000043214

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0003824	catalytic activity
GO:0004721	phosphoprotein phosphatase activity
GO:0004722	protein serine/threonine phosphatase activity
GO:0004741	[pyruvate dehydrogenase (lipoamide)] phosphatase activity
GO:0005509	calcium ion binding
GO:0016787	hydrolase activity
GO:0046872	metal ion binding