Version 5.4
Mus musculus Gene: Dsg1a
Summary
InnateDB Gene IDBG-129803.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Dsg1a
Gene Name desmoglein 1 alpha
Synonyms BB010119; Dsg1
Species Mus musculus
Ensembl Gene ENSMUSG00000069441
Encoded Proteins
IDBP-129805
desmoglein 1 alpha
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000134760:
Desmosomes are cell-cell junctions between epithelial, myocardial and certain other cell types. Desmoglein 1 is a calcium-binding transmembrane glycoprotein component of desmosomes in vertebrate epithelial cells. Currently, three desmoglein subfamily members have been identified and all are members of the cadherin cell adhesion molecule superfamily. These desmoglein gene family members are located in a cluster on chromosome 18. The protein encoded by this gene has been identified as the autoantigen of the autoimmune skin blistering disease pemphigus foliaceus. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 18:20310811-20343350
Strand Forward strand
Band A2
Transcripts
ENSMUST00000077146 ENSMUSP00000076393
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 23 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 23 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005509 calcium ion binding
GO:0005515 protein binding
Biological Process
GO:0007156 homophilic cell adhesion
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030057 desmosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000134760
View Gene Order
ENSBTAG00000013831
Not yet available
Pathways
NETPATH
REACTOME
REACT_258521
Apoptosis pathway
REACT_224460
Apoptotic cleavage of cellular proteins pathway
REACT_212869
Apoptotic cleavage of cell adhesion proteins pathway
REACT_207035
Apoptotic execution phase pathway
KEGG
mmu05150
Staphylococcus aureus infection pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_13579
Apoptotic cleavage of cell adhesion proteins pathway
REACT_107
Apoptotic cleavage of cellular proteins pathway
REACT_995
Apoptotic execution phase pathway
REACT_578
Apoptosis pathway
KEGG
hsa05150
Staphylococcus aureus infection pathway
INOH
PID NCI
Cross-References
SwissProt Q61495
TrEMBL
UniProt Splice Variant
Entrez Gene 13510
UniGene Mm.37953
RefSeq NM_010079 XM_006525597
OMIM
CCDS CCDS50231
HPRD
IMGT
MGI ID MGI:94930
MGI Symbol Dsg1a
EMBL AK029294 BC154410 X74335
GenPept AAI54411 BAC26378 CAA52382
RNA Seq Atlas 13510

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca