Version 5.4
Mus musculus Protein: Dsg1a
Summary
InnateDB Protein IDBP-129805.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Dsg1a
Protein Name desmoglein 1 alpha
Synonyms BB010119; Dsg1;
Species Mus musculus
Ensembl Protein ENSMUSP00000076393
InnateDB Gene IDBG-129803 (Dsg1a)
Protein Structure
UniProt Annotation
Function Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.
Subcellular Localization Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Cell junction, desmosome.
Disease Associations
Tissue Specificity Expressed in testis. {ECO:0000269PubMed:12631242}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 23 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 23 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005509 calcium ion binding
GO:0005515 protein binding
Biological Process
GO:0007156 homophilic cell adhesion
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030057 desmosome
Protein Structure and Domains
PDB ID MGI:94930
InterPro IPR000233 Cadherin, cytoplasmic domain
IPR002126 Cadherin
IPR009122 Desmosomal cadherin
IPR009123 Desmoglein
IPR015919 Cadherin-like
PFAM PF01049
PF00028
PRINTS PR00205
PR01818
PR01819
PIRSF
SMART SM00112
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q61495
PhosphoSite PhosphoSite-Q61495
TrEMBL
UniProt Splice Variant
Entrez Gene 13510
UniGene Mm.37953
RefSeq NP_034209
MGI ID
MGI Symbol Dsg1a
OMIM
CCDS CCDS50231
HPRD
IMGT
EMBL AK029294 BC154410 X74335
GenPept AAI54411 BAC26378 CAA52382

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca