InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: FGF6

Summary

InnateDB Gene

IDBG-12990.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FGF6

Gene Name

fibroblast growth factor 6

Synonyms

HBGF-6; HST2

Species

Homo sapiens

Ensembl Gene

ENSG00000111241

Encoded Proteins

IDBP-12992

fibroblast growth factor 6

IDBP-602261

fibroblast growth factor 6

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene displayed oncogenic transforming activity when transfected into mammalian cells. The mouse homolog of this gene exhibits a restricted expression profile predominantly in the myogenic lineage, which suggested a role in muscle regeneration or differentiation. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 12:4428155-4445614

Strand

Reverse strand

Band

p13.32

Transcripts

ENST00000228837	ENSP00000228837
ENST00000535390
ENST00000543077	ENSP00000445479

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005104	fibroblast growth factor receptor binding
GO:0008083	growth factor activity

Biological Process

GO:0001502	cartilage condensation
GO:0001525	angiogenesis
GO:0007165	signal transduction
GO:0007173	epidermal growth factor receptor signaling pathway
GO:0007267	cell-cell signaling
GO:0008283	cell proliferation
GO:0008284	positive regulation of cell proliferation
GO:0008286	insulin receptor signaling pathway
GO:0008543	fibroblast growth factor receptor signaling pathway
GO:0038095	Fc-epsilon receptor signaling pathway
GO:0045087	innate immune response
GO:0045445	myoblast differentiation
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0048015	phosphatidylinositol-mediated signaling
GO:0051781	positive regulation of cell division

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0042383	sarcolemma

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000000183

View Gene Order

ENSBTAG00000006800

Not yet available

Pathways

NETPATH

REACTOME

REACT_75829

PIP3 activates AKT signaling pathway

REACT_147814

DAP12 signaling pathway

REACT_147694

DAP12 interactions pathway

REACT_12464

PI3K/AKT activation pathway

REACT_12578

GAB1 signalosome pathway

REACT_9417

Signaling by EGFR pathway

REACT_115961

PI3K events in ERBB4 signaling pathway

REACT_115596

Signaling by ERBB4 pathway

REACT_976

PI3K Cascade pathway

REACT_498

Signaling by Insulin receptor pathway

REACT_150203

IRS-related events triggered by IGF1R pathway

REACT_150359

Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) pathway

REACT_116008

PI3K events in ERBB2 signaling pathway

REACT_115755

Signaling by ERBB2 pathway

REACT_111184

Negative regulation of FGFR signaling pathway

REACT_21310

Phospholipase C-mediated cascade pathway

REACT_21374

SHC-mediated cascade pathway

REACT_21270

PI-3K cascade pathway

REACT_21247

FRS2-mediated cascade pathway

REACT_9413

FGFR2c ligand binding and activation pathway

REACT_9515

FGFR1c ligand binding and activation pathway

REACT_9452

FGFR4 ligand binding and activation pathway

REACT_9470

Signaling by FGFR pathway

REACT_111040

Signaling by SCF-KIT pathway

REACT_17025

Downstream signal transduction pathway

REACT_16888

Signaling by PDGF pathway

REACT_120863

Activated point mutants of FGFR2 pathway

REACT_121153

Signaling by activated point mutants of FGFR1 pathway

REACT_121398

Signaling by FGFR mutants pathway

REACT_147727

Constitutive PI3K/AKT Signaling in Cancer pathway

REACT_120736

Signaling by FGFR in disease pathway

REACT_11061

Signalling by NGF pathway

REACT_115871

Signaling by EGFR in Cancer pathway

REACT_21272

Downstream signaling of activated FGFR pathway

REACT_163769

Role of LAT2/NTAL/LAB on calcium mobilization pathway

REACT_6802

Innate Immune System pathway

REACT_120999

Signaling by FGFR1 mutants pathway

REACT_163936

Fc epsilon receptor (FCERI) signaling pathway

REACT_111102

Signal Transduction pathway

REACT_332

IRS-mediated signalling pathway

REACT_75774

Adaptive Immune System pathway

REACT_6900

Immune System pathway

REACT_1195

Insulin receptor signalling cascade pathway

REACT_12056

NGF signalling via TRKA from the plasma membrane pathway

REACT_762

IRS-related events pathway

REACT_121155

Signaling by FGFR2 mutants pathway

REACT_150210

IGF1R signaling cascade pathway

REACT_147723

PI3K/AKT Signaling in Cancer pathway

REACT_9390

FGFR2 ligand binding and activation pathway

REACT_9396

FGFR ligand binding and activation pathway

REACT_118773

Signaling by the B Cell Receptor (BCR) pathway

REACT_118638

Downstream signaling events of B Cell Receptor (BCR) pathway

REACT_9483

FGFR1 ligand binding and activation pathway

REACT_116125

Disease pathway

KEGG

hsa04810

Regulation of actin cytoskeleton pathway

hsa04010

MAPK signaling pathway pathway

hsa05218

Melanoma pathway

hsa05200

Pathways in cancer pathway

INOH

INOH website

FGF signaling pathway pathway

INOH website

GPCR signaling pathway

PID NCI

syndecan_4_pathway

Syndecan-4-mediated signaling events

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.166015

RefSeq

NM_020996

HUGO

OMIM

CCDS

CCDS8527

HPRD

00623

IMGT

EMBL

GenPept

RNA Seq Atlas