InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: FGF6

Summary

InnateDB Protein

IDBP-12992.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FGF6

Protein Name

fibroblast growth factor 6

Synonyms

HBGF-6; HST2;

Species

Homo sapiens

Ensembl Protein

ENSP00000228837

InnateDB Gene

IDBG-12990 (FGF6)

Protein Structure

UniProt Annotation

Function

Plays an important role in the regulation of cell proliferation, cell differentiation, angiogenesis and myogenesis, and is required for normal muscle regeneration. {ECO:0000269PubMed:8663044}.

Subcellular Localization

Secreted, extracellular space.

Disease Associations

Tissue Specificity

Leukemia cell lines with platelet/ megakaryocytic differentiation potential.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005104	fibroblast growth factor receptor binding
GO:0008083	growth factor activity

Biological Process

GO:0001502	cartilage condensation
GO:0001525	angiogenesis
GO:0007165	signal transduction
GO:0007173	epidermal growth factor receptor signaling pathway
GO:0007267	cell-cell signaling
GO:0008283	cell proliferation
GO:0008284	positive regulation of cell proliferation
GO:0008286	insulin receptor signaling pathway
GO:0008543	fibroblast growth factor receptor signaling pathway
GO:0038095	Fc-epsilon receptor signaling pathway
GO:0045087	innate immune response
GO:0045445	myoblast differentiation
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0048015	phosphatidylinositol-mediated signaling
GO:0051781	positive regulation of cell division