InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Ndufa5

Summary

InnateDB Gene

IDBG-130087.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ndufa5

Gene Name

NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 5

Synonyms

2900002J19Rik

Species

Mus musculus

Ensembl Gene

ENSMUSG00000023089

Encoded Proteins

IDBP-130089

NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 5

IDBP-401616

NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 5

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000128609:
The human NDUFA5 gene codes for the B13 subunit of complex I of the respiratory chain, which transfers electrons from NADH to ubiquinone. The high degree of conservation of NDUFA5 extending to plants and fungi indicates its functional significance in the enzyme complex. The protein localizes to the inner mitochondrial membrane as part of the 7 component-containing, water soluble "iron-sulfur protein" (IP) fraction of complex I, although its specific role is unknown. It is assumed to undergo post-translational removal of the initiator methionine and N-acetylation of the next amino acid. The predicted secondary structure is primarily alpha helix, but the carboxy-terminal half of the protein has high potential to adopt a coiled-coil form. The amino-terminal part contains a putative beta sheet rich in hydrophobic amino acids that may serve as mitochondrial import signal. Related pseudogenes have also been identified on four other chromosomes. [provided by RefSeq, Jul 2008]
This nuclear gene encodes a conserved protein that comprises the B13 subunit of complex I of the mitochondrial respiratory chain. The encoded protein localizes to the inner mitochondrial membrane, where it is thought to aid in the transfer of electrons from NADH to ubiquinone. Alternative splicing results in multiple transcript variants. There are numerous pseudogenes of this gene on chromosomes 1, 3, 6, 8, 9, 11, 12, and 16. [provided by RefSeq, Apr 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:24518666-24528013

Strand

Reverse strand

Band

A3.1

Transcripts

ENSMUST00000023851	ENSMUSP00000023851
ENSMUST00000118558	ENSMUSP00000112971
ENSMUST00000132588
ENSMUST00000141274

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.