Version 5.4
Mus musculus Gene: Pex2
Summary
InnateDB Gene IDBG-130409.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Pex2
Gene Name peroxisomal biogenesis factor 2
Synonyms D3Ertd138e; PAF-1; PMP35; Pxmp3
Species Mus musculus
Ensembl Gene ENSMUSG00000040374
Encoded Proteins
IDBP-130411
peroxisomal membrane protein 3
IDBP-130413
peroxisomal membrane protein 3
IDBP-626917
peroxisomal membrane protein 3
IDBP-626918
peroxisomal membrane protein 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000164751:
This gene encodes an integral peroxisomal membrane protein required for peroxisome biogenesis. The protein is thought to be involved in peroxisomal matrix protein import. Mutations in this gene result in one form of Zellweger syndrome and infantile Refsum disease. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:5560188-5576239
Strand Reverse strand
Band A1
Transcripts
ENSMUST00000059021 ENSMUSP00000059415
ENSMUST00000071280 ENSMUSP00000071255
ENSMUST00000164828 ENSMUSP00000129311
ENSMUST00000165309 ENSMUSP00000126445
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Predicted by orthology
Total 9 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008270 zinc ion binding
Biological Process
GO:0000038 very long-chain fatty acid metabolic process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001764 neuron migration
GO:0006635 fatty acid beta-oxidation
GO:0006699 bile acid biosynthetic process
GO:0007031 peroxisome organization
GO:0007399 nervous system development
GO:0016558 protein import into peroxisome matrix
GO:0031648 protein destabilization
GO:0042632 cholesterol homeostasis
GO:0045540 regulation of cholesterol biosynthetic process
GO:0048147 negative regulation of fibroblast proliferation
GO:0050680 negative regulation of epithelial cell proliferation
Cellular Component
GO:0005777 peroxisome
GO:0005778 peroxisomal membrane
GO:0005779 integral component of peroxisomal membrane
GO:0016020 membrane
GO:0016593 Cdc73/Paf1 complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000164751
View Gene Order
ENSBTAG00000003885
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu04146
Peroxisome pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa04146
Peroxisome pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001163301 NM_001163302 NM_001163305 NM_001163306 NM_001267714 NM_001267715 NM_008994
OMIM
CCDS CCDS17228
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca