InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Fbxo5

Summary

InnateDB Gene

IDBG-130439.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Fbxo5

Gene Name

F-box protein 5

Synonyms

2510044I10Rik; C85305; Emi1; Fbxo31

Species

Mus musculus

Ensembl Gene

ENSMUSG00000019773

Encoded Proteins

IDBP-130441

F-box protein 5

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000112029:
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. This protein is similar to xenopus early mitotic inhibitor-1 (Emi1), which is a mitotic regulator that interacts with Cdc20 and inhibits the anaphase promoting complex. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Dec 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 10:5799160-5805600

Strand

Reverse strand

Band

Transcripts

ENSMUST00000019907	ENSMUSP00000019907
ENSMUST00000142200

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 31 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	31 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0019901	protein kinase binding
GO:0046872	metal ion binding

Biological Process

GO:0001556	oocyte maturation
GO:0007057	spindle assembly involved in female meiosis I
GO:0007067	mitotic nuclear division
GO:0007346	regulation of mitotic cell cycle
GO:0016050	vesicle organization
GO:0016567	protein ubiquitination
GO:0040020	regulation of meiosis
GO:0045835	negative regulation of meiosis
GO:0046785	microtubule polymerization
GO:0051225	spindle assembly
GO:0051436	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051442	negative regulation of ubiquitin-protein ligase activity involved in meiotic cell cycle
GO:0060565	inhibition of mitotic anaphase-promoting complex activity
GO:0060903	positive regulation of meiosis I