InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Il7

Summary

InnateDB Gene

IDBG-130583.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Il7

Gene Name

interleukin 7

Synonyms

A630026I06Rik; hlb368; Il-7

Species

Mus musculus

Ensembl Gene

ENSMUSG00000040329

Encoded Proteins

IDBP-626946

interleukin 7

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 26034215

Il7 is produced by intestinal epithelial cells in response to Citrobacter rodentium infection and plays a critical role in the protective immunity against this intestinal attaching and effacing bacterium.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000104432:
The protein encoded by this gene is a cytokine important for B and T cell development. This cytokine and the hepatocyte growth factor (HGF) form a heterodimer that functions as a pre-pro-B cell growth-stimulating factor. This cytokine is found to be a cofactor for V(D)J rearrangement of the T cell receptor beta (TCRB) during early T cell development. This cytokine can be produced locally by intestinal epithelial and epithelial goblet cells, and may serve as a regulatory factor for intestinal mucosal lymphocytes. Knockout studies in mice suggested that this cytokine plays an essential role in lymphoid cell survival. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional splice variants have been described but their presence in normal tissues has not been confirmed.[provided by RefSeq, Dec 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:7572077-7613427

Strand

Reverse strand

Band

Transcripts

ENSMUST00000168269

ENSMUSP00000126219

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	1 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005125	cytokine activity
GO:0005126	cytokine receptor binding
GO:0005139	interleukin-7 receptor binding
GO:0005515	protein binding
GO:0008083	growth factor activity

Biological Process

GO:0002360	T cell lineage commitment
GO:0006955	immune response
GO:0010468	regulation of gene expression
GO:0030890	positive regulation of B cell proliferation
GO:0043086	negative regulation of catalytic activity
GO:0045087	innate immune response (InnateDB)
GO:0045453	bone resorption
GO:0045582	positive regulation of T cell differentiation
GO:0046622	positive regulation of organ growth
GO:0048873	homeostasis of number of cells within a tissue
GO:2001237	negative regulation of extrinsic apoptotic signaling pathway
GO:2001240	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand