Version 5.4
Homo sapiens Gene: IL7
Summary
InnateDB Gene IDBG-26153.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IL7
Gene Name interleukin 7
Synonyms IL-7
Species Homo sapiens
Ensembl Gene ENSG00000104432
Encoded Proteins
IDBP-26155
interleukin 7
IDBP-26159
interleukin 7
IDBP-477703
interleukin 7
IDBP-484985
interleukin 7
IDBP-477415
interleukin 7
IDBP-475014
interleukin 7
IDBP-592051
interleukin 7
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 26034215
[Mus musculus] Il7 is produced by intestinal epithelial cells in response to Citrobacter rodentium infection and plays a critical role in the protective immunity against this intestinal attaching and effacing bacterium.
Entrez Gene
Summary The protein encoded by this gene is a cytokine important for B and T cell development. This cytokine and the hepatocyte growth factor (HGF) form a heterodimer that functions as a pre-pro-B cell growth-stimulating factor. This cytokine is found to be a cofactor for V(D)J rearrangement of the T cell receptor beta (TCRB) during early T cell development. This cytokine can be produced locally by intestinal epithelial and epithelial goblet cells, and may serve as a regulatory factor for intestinal mucosal lymphocytes. Knockout studies in mice suggested that this cytokine plays an essential role in lymphoid cell survival. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional splice variants have been described but their presence in normal tissues has not been confirmed.[provided by RefSeq, Dec 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:78675743-78805523
Strand Reverse strand
Band q21.13
Transcripts
ENST00000263851 ENSP00000263851
ENST00000379113 ENSP00000368408
ENST00000523959
ENST00000519833
ENST00000518982 ENSP00000430272
ENST00000520269 ENSP00000427750
ENST00000520215 ENSP00000428364
ENST00000520317 ENSP00000427800
ENST00000521323
ENST00000541183 ENSP00000438922
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
Experimentally validated
Total 9 [view]
Protein-Protein 7 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005125 cytokine activity
GO:0005126 cytokine receptor binding
GO:0005139 interleukin-7 receptor binding
GO:0005515 protein binding
GO:0008083 growth factor activity
Biological Process
GO:0002360 T cell lineage commitment
GO:0006955 immune response
GO:0006959 humoral immune response
GO:0007267 cell-cell signaling
GO:0008284 positive regulation of cell proliferation
GO:0009887 organ morphogenesis
GO:0010468 regulation of gene expression
GO:0030890 positive regulation of B cell proliferation
GO:0043066 negative regulation of apoptotic process
GO:0043086 negative regulation of catalytic activity
GO:0045453 bone resorption
GO:0045582 positive regulation of T cell differentiation
GO:0046622 positive regulation of organ growth
GO:0048873 homeostasis of number of cells within a tissue
GO:2001237 negative regulation of extrinsic apoptotic signaling pathway
GO:2001240 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000040329
View Gene Order
ENSBTAG00000016284
Not yet available
Pathways
NETPATH
NetPath_19
IL-7 pathway
REACTOME
REACT_115529
Interleukin-7 signaling pathway
REACT_75790
Cytokine Signaling in Immune system pathway
REACT_6900
Immune System pathway
REACT_22232
Signaling by Interleukins pathway
KEGG
hsa04640
Hematopoietic cell lineage pathway
hsa04060
Cytokine-cytokine receptor interaction pathway
hsa04630
Jak-STAT signaling pathway pathway
INOH
INOH website
IL-7 signaling pathway
INOH website
JAK STAT pathway and regulation pathway
INOH website
GPCR signaling pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.591873
RefSeq NM_000880 NM_001199886 NM_001199887 NM_001199888
HUGO
OMIM
CCDS CCDS56541 CCDS6224 CCDS75755 CCDS75756
HPRD 00892
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca