InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Pax4

Summary

InnateDB Gene

IDBG-130592.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pax4

Gene Name

paired box gene 4

Synonyms

Pax-4

Species

Mus musculus

Ensembl Gene

ENSMUSG00000029706

Encoded Proteins

IDBP-130594

paired box gene 4

IDBP-624544

paired box gene 4

IDBP-624545

paired box gene 4

IDBP-624546

paired box gene 4

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000106331:
This gene is a member of the paired box (PAX) family of transcription factors. Members of this gene family typically contain a paired box domain, an octapeptide, and a paired-type homeodomain. These genes play critical roles during fetal development and cancer growth. The paired box 4 gene is involved in pancreatic islet development and mouse studies have demonstrated a role for this gene in differentiation of insulin-producing beta cells. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:28442334-28449353

Strand

Reverse strand

Band

A3.3

Transcripts

ENSMUST00000031718	ENSMUSP00000031718
ENSMUST00000164519	ENSMUSP00000131301
ENSMUST00000171089	ENSMUSP00000126000
ENSMUST00000174194	ENSMUSP00000134470
ENSMUST00000174423
ENSMUST00000174036

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0001206	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0003677	DNA binding
GO:0003690	double-stranded DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007623	circadian rhythm
GO:0009887	organ morphogenesis
GO:0030154	cell differentiation
GO:0031018	endocrine pancreas development
GO:0042493	response to drug
GO:0043066	negative regulation of apoptotic process
GO:0045595	regulation of cell differentiation
GO:0045597	positive regulation of cell differentiation
GO:0045892	negative regulation of transcription, DNA-templated
GO:0051591	response to cAMP
GO:0060041	retina development in camera-type eye

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005667	transcription factor complex

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000106331

View Gene Order

ENSBTAG00000000410

Not yet available

Pathways

NETPATH

REACTOME

KEGG

mmu04950

Maturity onset diabetes of the young pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_13650

Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells pathway

REACT_111045

Developmental Biology pathway

REACT_13698

Regulation of beta-cell development pathway

KEGG

hsa04950

Maturity onset diabetes of the young pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.8026

RefSeq

NM_001159925 NM_001159926 NM_011038

OMIM

CCDS

CCDS39447 CCDS51731 CCDS51732

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas