InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Pax4

Summary

InnateDB Protein

IDBP-624544.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pax4

Protein Name

paired box gene 4

Synonyms

Pax-4;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000131301

InnateDB Gene

IDBG-130592 (Pax4)

Protein Structure

UniProt Annotation

Function

Plays an important role in the differentiation and development of pancreatic islet beta cells. Transcriptional repressor that competes with PAX6 in binding to a common element in the glucagon, insulin and somatostatin promoters.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Expressed in early pancreas. Later restricted to beta cells. Undetectable in adult islets.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0001206	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0003677	DNA binding
GO:0003690	double-stranded DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007623	circadian rhythm
GO:0009887	organ morphogenesis
GO:0030154	cell differentiation
GO:0031018	endocrine pancreas development
GO:0042493	response to drug
GO:0043066	negative regulation of apoptotic process
GO:0045595	regulation of cell differentiation
GO:0045597	positive regulation of cell differentiation
GO:0051591	response to cAMP
GO:0060041	retina development in camera-type eye